Association between trajectories of systolic blood pressure and frailty outcome in middle-aged and older adults.

OBJECTIVES: The association between blood pressure and frailty outcome in the middle-aged and older population remains controversial. This study aimed to examine the relationship between trajectories of systolic blood pressure (SBP) and new-onset frailty. DESIGN: Cohort study with a 7-year follow-up. SETTING AND PARTICIPANTS: Data were derived from 4 waves (2011, 2013, 2015 and 2018) of the China Health and Retirement Longitudinal Study and 6168 participants aged ≥45 years were included in the study. METHODS: The frailty index (FI) was constructed based on 40 scored items, with FI ≥ 0.25 defined as frailty. We identified the 5-year trajectory of SBP by latent class trajectory modeling. The association between SBP trajectories and frailty was explored based on hazard ratios (HR) by four Cox proportional hazards models. Furthermore, we also investigated the relationship between mean SBP and systolic blood pressure variability (SBPV) and frailty. RESULTS: 6168 participants were included in this study with a mean age of 59 years. We identified five trajectories based on SBP, which are maintained low-stable SBP (T0), moderate-stable SBP (T1), remitting then increasing SBP (T2), increasing then remitting SBP (T3), and remaining stable at high SBP levels (T4). During the 7-year follow-up period, frailty outcome occurred in 1415 participants. After adjusting for other confounders, the two trajectories labeled "T2" and "T4" were associated with a higher risk of frailty compared with T0. In addition, elevated SBP and increased SBPV were associated with risk of frailty. CONCLUSIONS: Higher risk of frailty occurred in two trajectories, remitting then increasing and remaining stable at high SBP levels, were associated with a relatively higher risk of frailty.

Fruit Intake and Alzheimer's Disease: Results from Mendelian Randomization.

Alzheimer's disease (AD) is the leading cause of dementia in old age, recognized as a global health priority. To explore causal effects of fresh fruit intake and dried fruit intake on AD liability, this study utilized GWAS from the UK Biobank and FinnGen to conduct Mendelian randomization (MR) analysis, and used inverse variance weighted (IVW), MR-Egger, and weighted median approaches for MR estimates, and visual inspections judged result stability. Results suggested little evidence of a potential causal relationship between fresh fruit intake and AD (OR=0.97, 95%CI=0.50-1.91, P=0.939), while significant, robust causality was indicated between dried fruit intake and AD (OR=4.09, 95%CI=2.07-8.10, P<0.001). Stability evaluations showed no heterogeneity or pleiotropy affecting interpretability and credibility of primary analyses. In conclusion, we strengthened evidence for positive causality from dried fruit intake to AD liability, with causality from fresh fruit intake on AD risk was not demonstrated.

[Outcomes and care practices of extremely preterm infants at 22-25 weeks' gestation age from the Chinese Neonatal Network].

Objective: To describe the current status and trends in the outcomes and care practices of extremely preterm infants at 22-25 weeks' gestation age from the Chinese Neonatal Network (CHNN) from 2019 to 2021. Methods: This cross-sectional study used data from the CHNN cohort of very preterm infants. All 963 extremely preterm infants with gestational age between 22-25 weeks who were admitted to neonatal intensive care units (NICU) of the CHNN from 2019 to 2021 were included. Infants admitted after 24 hours of life or transferred to non-CHNN hospitals were excluded. Perinatal care practices, survival rates, incidences of major morbidities, and NICU treatments were described according to different gestational age groups and admission years. Comparison among gestational age groups was conducted using χ2 and Kruskal-Wallis tests. Trends by year were evaluated by Cochran-Armitage and Jonckheere-Terpstra tests for trend. Results: Of the 963 extremely preterm infants enrolled, 588 extremely preterm infants (61.1%) were male. The gestational age was 25.0 (24.4, 25.6) weeks, with 29 extremely preterm infants (3.0%), 88 extremely preterm infants (9.1%), 264 extremely preterm infants (27.4%), and 582 extremely preterm infants (60.4%) at 22, 23, 24, and 25 weeks of gestation age, respectively. The birth weight was 770 (680, 840) g. From 2019 to 2021, the number of extremely preterm infants increased each year (285, 312, and 366 extremely preterm infants, respectively). Antenatal steroids and magnesium sulfate were administered to 67.7% (615/908) and 51.1% (453/886) mothers of extremely preterm infants. In the delivery room, 20.8% (200/963) and 69.5% (669/963) extremely preterm infants received noninvasive positive end-expiratory pressure support and endotracheal intubation. Delayed cord clamping and cord milking were performed in 19.0% (149/784) and 30.4% (241/794) extremely preterm infants. From 2019 to 2021, there were significant increases in the usage of antenatal steroids, antenatal magnesium sulfate, and delivery room noninvasive positive-end expiratory pressure support (all P<0.05). Overall, 349 extremely preterm infants (36.2%) did not receive complete care, 392 extremely preterm infants (40.7%) received complete care and survived to discharge, and 222 extremely preterm infants (23.1%) received complete care but died in hospital. The survival rates for extremely preterm infants at 22, 23, 24 and 25 weeks of gestation age were 10.3% (3/29), 23.9% (21/88), 33.0% (87/264) and 48.3% (281/582), respectively. From 2019 to 2021, there were no statistically significant trends in complete care, survival, and mortality rates (all P>0.05). Only 11.5% (45/392) extremely preterm infants survived without major morbidities. Moderate to severe bronchopulmonary dysplasia (67.3% (264/392)) and severe retinopathy of prematurity (61.5% (241/392)) were the most common morbidities among survivors. The incidences of severe intraventricular hemorrhage or periventricular leukomalacia, necrotizing enterocolitis, and sepsis were 15.3% (60/392), 5.9% (23/392) and 19.1% (75/392), respectively. Overall, 83.7% (328/392) survivors received invasive ventilation during hospitalization, with a duration of 22 (10, 42) days. The hospital stay for survivors was 97 (86, 116) days. Conclusions: With the increasing number of extremely preterm infants at 22-25 weeks' gestation admitted to CHNN NICU, the survival rate remained low, especially the rate of survival without major morbidities. Further quality improvement initiatives are needed to facilitate the implementation of evidence-based care practices.

Advocacy e condições de trabalho na universidade: Estratégia para o empoderamento do docente de enfermagem / Advocacy and working conditions at the university: A strategy for the empowerment of nursing teachers / Advocacy y condiciones laborales en la universidad: Estrategia para el empoderamiento del profesorado de enfermería

Resumo Enquadramento: No campo da enfermagem a advocacy procura contribuir no direito à saúde, que se insere no campo dos direitos humanos, pois está intrinsecamente relacionado ao direito de todos a uma vida saudável. Objetivo: Analisar a perceção de docentes sobre a advocacy na enfermagem e discutir as estratégias de promoção de advocacy para o trabalhador docente universitário de enfermagem. Metodologia: Estudo descritivo e exploratório, de abordagem qualitativa realizado em duas universidades públicas situadas no município do Rio de Janeiro, Brasil. Os participantes foram 14 docentes de enfermagem. Utilizou-se o grupo focal e os dados foram analisados à luz da técnica de análise de conteúdo. Resultados: Destaca-se a advocacy como atividade imperativa para alcançar a defesa dos interesses da categoria profissional, bem como a utilização das mídias como estratégia de divulgação do trabalho da enfermagem, incluindo os docentes de enfermagem. Conclusão: A advocacy é uma estratégia de promoção e valorização dos docentes de enfermagem em universidades sendo necessário o investimento nessa estratégia como importante recurso para a promoção da valorização profissional.

Abstract Background: In nursing, advocacy seeks to contribute to the right to health, which is intrinsically related to the human right to a healthy life. Objective: To analyze university teachers' perceptions of advocacy in nursing and discuss strategies to promote advocacy for university nursing teachers. Methodology: A descriptive and exploratory study with a qualitative approach was carried out in two public universities in Rio de Janeiro, Brazil. The participants were 14 nursing teachers. A focus group was conducted, and data were analyzed using the content analysis technique. Results: Advocacy stands out as a crucial activity to defend the professional category's interests, using the media as a strategy for disseminating nursing work, including nursing teachers. Conclusion: An investment in advocacy is needed as it is a strategy for valuing university nursing teachers and promoting their professional development.

Resumen Marco contextual: En el ámbito de la enfermería, la advocacy pretende contribuir al derecho a la salud, que se enmarca en el ámbito de los derechos humanos, ya que está intrínsecamente relacionado con el derecho de todos a una vida sana. Objetivo: Analizar la percepción de los profesores sobre la advocacy en la enfermería y debatir estrategias para promover la advocacy para el trabajador docente universitario de enfermería. Metodología: Estudio descriptivo y exploratorio de enfoque cualitativo realizado en dos universidades públicas localizadas en el municipio de Río de Janeiro, Brasil. Los participantes fueron 14 profesores de enfermería. Se utilizó el grupo focal y los datos fueron analizados con la técnica de análisis de contenido. Resultados: Se destaca la advocacy como actividad imprescindible para lograr la defensa de los intereses de la categoría profesional, así como la utilización de los medios de comunicación como estrategia de difusión del trabajo de enfermería, incluidos los docentes de enfermería. Conclusión: La advocacy es una estrategia de promoción y valoración del profesorado de enfermería en las universidades y es necesario invertir en esta estrategia como recurso fundamental para la promoción de la valoración profesional.

Influência do contexto político-institucional na tomada de decisões de docentes de enfermagem sobre a aposentadoria / Influence of the political-institutional context on nursing professors' decision-making about retirement / Influencia del contexto político-institucional en la toma de decisiones de los profesores de enfermería sobre la jubilación

Objetivo: compreender as percepções de docentes de enfermagem aposentados de uma universidade pública sobre a influência do contexto político-institucional na tomada de decisão pela aposentadoria. Método: pesquisa qualitativa, realizada com 13 docentes de enfermagem aposentados de uma universidade pública do estado do Rio de Janeiro, Brasil. Dados coletados entre março e abril de 2022, mediante entrevista semiestruturada, submetida à análise lexical apoiada pelo software Iramuteq. Resultados: os léxicos "reforma da previdência", "medo", "salário" e "greve" apontaram para um contexto de incerteza vivenciado pelos docentes, o qual influenciou na decisão pela aposentadoria. Considerações finais: a decisão pela aposentadoria é complexa, pois é marcada não somente pelas questões pessoais, como também pela relação que o docente estabelece com o trabalho e a instituição, bem como pela percepção que tem sobre o contexto social, econômico e político. Nesse cenário, os docentes de enfermagem aposentam-se com pesar e precocemente, em função dos riscos associados à perda de direitos(AU)

Objective: to understand the perception of retired nursing professors at a public university about the influence of the political-institutional context on decision-making for retirement. Method: qualitative research, carried out with 13 retired nursing professors from a public university in the state of Rio de Janeiro. Data were collected through semi-structured interviews submitted to lexical analysis supported by the Iramuteq software. Results: the lexicons pension reform, fear, salary and strike pointed to a context of uncertainty experienced by teachers which influenced the decision to retire. Final considerations: the decision to retire is complex, as it is marked not only by personal issues, but by the relationship that the professor establishes with work and the institution, as well as the perception he has of the social, economic and political context. In this scenario, nursing professors retire with regret and early due to the risks associated with the loss of rights(AU)

Objetivo: comprender la percepción de profesores de enfermería jubilados de una universidad pública sobre la influencia del contexto político-institucional en la toma de decisiones respecto a la jubilación. Método: investigación cualitativa, realizada con 13 enfermeros docentes de enfermería, jubilados de una universidad pública del estado de Río de Janeiro, Brasil. Los datos se recopilaron entre marzo y abril de 2022, a través de entrevistas semiestructuradas sometidas al análisis léxico con el apoyo del software Iramuteq. Resultados: los léxicos reforma previsional, miedo, salario y huelga señalaron un contexto de incertidumbre experimentado por los docentes, lo que influyó en su decisión de jubilarse. Conclusión: la decisión de jubilarse es compleja, ya que está marcada no solo por cuestiones personales, sino también por la relación que el profesor establece con el trabajo y la institución, así como por su percepción del contexto social, económico y político. En este escenario, los docentes de enfermería se jubilan con pesar y a una edad temprana debido a los riesgos asociados con la pérdida de derechos(AU)

Qualidade de vida no trabalho dos docentes de enfermagem universitários na modernidade líquida / Quality of work life of university nursing teacher in liquid modernity / Calidad de vida laboral de profesores universitarios del área de enfermería en la modernidad líquida

Objetivo: analisar a qualidade de vida no trabalho dos docentes de enfermagem universitários, considerando a configuração do mundo líquido. Método: estudo qualitativo, descritivo, de abordagem qualitativa, realizado em duas universidades públicas. Os participantes do estudo foram 14 docentes de enfermagem pertencentes às universidades. Para a coleta de dados foi utilizado o grupo focal e os dados foram analisados à luz da técnica de análise de conteúdo. Resultados: observa-se excesso de atividades e cobrança exacerbada refletindo na sobrecarga de trabalho, bem como desmonte das universidades públicas ocasionando instabilidade no processo de trabalho e consequente condições laborais inadequadas. Considerações finais: o trabalho docente no mundo líquido guarda características diferenciadas inerentes à prática da educação, quando comparada a outros grupos de trabalhadores. Assim, configura-se a necessidade de investimento nas universidades públicas a fim de proporcionar a disponibilização de verbas para o desenvolvimento do ensino, pesquisa e extensão, no incremento da ciência e tecnologia(AU)

Objective: to analyze the quality of life at work of university nursing professors, considering the configuration of the liquid world. Method: qualitative, descriptive study, with a qualitative approach, carried out in two public universities. Study participants were 14 nursing professors belonging to universities. For data collection, a focus group was used and the data were analyzed using the content analysis technique. Results: there is an excess of activities and exacerbated demands, reflecting on work overload, as well as the dismantling of public universities, causing instability in the work process and consequent inadequate working conditions. Final considerations: the teaching work in the liquid world has different characteristics inherent to the practice of education, when compared to other groups of workers. Thus, there is a need for investment in public universities in order to provide funds for the development of teaching, research and extension, in the increment of science and technology(AU)

Objetivo: analizar la calidad de vida en el trabajo de profesores universitarios de enfermería, considerando la configuración del mundo líquido. Método: estudio descriptivo, con enfoque cualitativo, realizado en dos universidades públicas. 14 profesores de enfermería pertenecientes a universidades participaron en el estudio. Para la recolección de datos se utilizó un grupo focal y se analizaron los datos mediante la técnica de análisis de contenido. Resultados: hay un exceso de actividades y exigencias exageradas, lo que se refleja en la sobrecarga de trabajo, así como el desmantelamiento de las universidades públicas, lo que provoca inestabilidad en el proceso de trabajo y consecuentemente condiciones de trabajo inadecuadas. Consideraciones finales: el trabajo docente en el mundo líquido tiene características diferentes inherentes a la práctica de la educación, cuando se compara con otros grupos de trabajadores. Por lo tanto, existe la necesidad de invertir en las universidades públicas con fines de poner a disposición fondos para el desarrollo de la enseñanza, la investigación y la extensión, en el incremento de la ciencia y la tecnología(AU)

[Summary of the 14th Asia Pacific Burn Congress, the 18th Chinese Symposium on Burn Medicine, and the 2023 Huaxia Burn Forum].

The 14th Asia Pacific Burn Congress, the 18th Chinese Symposium on Burn Medicine, and the 2023 Huaxia Burn Forum was held successfully in Chongqing from September 13th to 16th, 2023. More than 1 000 participants from more than 10 countries and regions attended the congress, including over 100 overseas experts. The theme of the congress was homage, heritage, and innovation, and three-day academic exchange was held in the form of academician forum, keynote forum, and seven thematic sub-forums focused on the hot spots and difficulties in the fields of burns, trauma, wound repair, and related fields. The congress was compact, comprehensive, in-depth, and fruitful, with warm atmosphere at the meeting site.

[Long-term outcomes of childhood steroid-sensitive nephrotic syndrome].

Objective: To investigate the long-term outcomes and risk factors in children with steroid-sensitive nephrotic syndrome (SSNS). Methods: A retrospective cohort study was conducted on newly onset SSNS admitted to the Department of Pediatrics of the First Affiliated Hospital of Sun Yat-sen University from January 2006 to December 2010 and 105 cases with follow-up for more than 10 years were included. Clinical data including general characteristics, clinical manifestation, laboratory tests, treatment and prognosis. The primary outcome was the clinical cure, and the secondary outcomes were relapse or ongoing immunosuppressive treatment within the last 1 year of follow-up and complications at the last follow-up. According to the primary outcome, the patients were divided into clinical cured group and uncured group. Categorical variables were compared between 2 groups using the χ2 or Fisher exact test, and continuous variables by t or Mann-Whitney U test. Multiple Logistic regression models were used for multivariate analysis. Results: Of the 105 children with SSNS, the age of onset was 3.0 (2.1, 5.0) years, and 82 (78.1%) were boys, 23(21.9%) were girls. The follow-up time was (13.1±1.4) years; 38 patients (36.2%) had frequently relapsing or steroid-dependent nephrotic syndrome (FRNS or SDNS) and no death or progression to end-stage kidney disease. Eighty-eight patients (83.8%) were clinically cured. Seventeen patients (16.2%) did not reach the clinical cure criteria, and 14 patients (13.3%) had relapsed or ongoing immunosuppressive treatment within the last year of follow-up. The proportion of FRNS or SDNS (12/17 vs. 29.5% (26/88), χ2=10.39), the proportion of treatment with second-line immunosuppressive therapy (13/17 vs. 18.2% (16/88), χ2=21.39), and the level of apolipoprotein A1 at onset ((2.0±0.5) vs. (1.7±0.6) g/L, t=2.02) in the uncured group were higher than those in the clinical cured group (all P<0.05). Multivariate Logistic regression analysis showed that patients treated with immunosuppressive therapy had an increased risk of not reaching clinical cure in the long term (OR=14.63, 95%CI 4.21-50.78, P<0.001). Of the 55 clinically cured patients who had relapsed, 48 patients (87.3%) did not relapse after 12 years of age. The age at last follow-up was 16.4 (14.6, 18.9) years, and 34 patients (32.4%) were ≥18 years of age. Among the 34 patients who had reached adulthood, 5 patients (14.7%) still relapsed or ongoing immunosuppressive treatment within the last year of follow-up. At the last follow-up, among the 105 patients, 13 still had long-term complications, and 8 patients were FRNS or SDNS. The proportion of FRNS or SDNS patients with short stature, obesity, cataracts, and osteoporotic bone fracture was 10.5% (4/38), 7.9% (3/38), 5.3% (2/38), and 2.6% (1/38), respectively. Conclusions: The majority of SSNS children were clinically cured, indicating a favorable long-term prognosis. History of treatment with second-line immunosuppressive therapy was the independent risk factor for patients not reaching the clinical cure criteria in the long term. While it is not uncommon for children with SSNS to persist into adulthood. The prevention and control of long-term complications of FRNS or SDNS patients should be strengthened.

Pejotização and implications for nursing work in Brazil: repercussions of neoliberalism.

OBJECTIVE: To analyze pejotização in the context of nursing work and the respective implications for the protection and health of these professionals. METHOD: Documentary study, which had news, resolutions, and recommendations issued by the Federal Nursing Council and the Regional Nursing Councils as data collection source, which underwent lexical analysis, based on data processing using the software Iramuteq. RESULTS: Six news items were captured for analysis. The similitude analysis was built with 40 active forms and six discussion centers were generated, with the most expressive lexicons in each of these being outsourcing, economic, pejotização, deputy, Federal Nursing Council, Bill of Law. CONCLUSION: In the quest to increase capital based on neoliberal ideas, strategies are produced that put the workers' and users' health and safety at risk. Pejotização leads to loss of labor rights, as it deprives the worker of consolidated labor achievements, such as the 13th salary, paid vacations, sick leave and, above all, insecurities are generated in relation to the future, with few guarantees, causing negative impacts on these workers' health.

[Efficacy and safety of low-dose rasburicase for refractory chronic gouty arthritis].

Objective: To explore the efficacy and safety of low-dose rasburicase for refractory chronic gouty arthritis. Methods: A cohort study. The clinical data of patients with refractory chronic gouty arthritis who were treated with rasburicase at Sun Yat-sen Memorial Hospital, Sun Yat-sen University between January 2021 and July 2022 were retrospectively analyzed. Refractory chronic gouty arthritis was defined as serum uric acid (sUA)>360 µmol/L and urate volume>10 cm3 under dual-energy computed tomography after tolerable maximal oral urate-lowering therapy for at least 3 months. The administration of low-dose rasburicase was applied intravenously with total dosage ranging from 4.5 to 7.5 mg each dose, at 4-week intervals for a maximum of three doses. Efficacy was evaluated by the changes of sUA level, tophus and urate volume. Results: A total of 22 patients were included for analysis, with 95.4% (21/22) male, the mean age was (44±15) years, and the median duration of gout was 11 (6-15) years. The mean sUA at baseline was (667±112) µmol/L. The levels of sUA significantly decreased after each dose of rasburicase (P<0.001), and the median reduction of sUA after each dose of rasburicase was 568 (471-635), 187 (66-335) and 123 (49-207) µmol/L, respectively. At week 12, nine patients (40.9%) exhibited sUA<360 µmol/L and tophus disappeared in one patient. The urate volume significantly decreased at week 12 when compared with that before the first dose of rasburicase in all the patients [40 (16-172) cm3 vs 17 (7-134) cm3, P<0.001], with a median reduction rate of 41.6% (22.9%-58.5%). The everall safety of rasburicase was good, and no serious adverse reactions occurred. Conclusions: Low-dose rasburicase is well-tolerated and effective for decreasing the urate burden in patients with refractory chronic gouty arthritis. Further prospective randomized controlled trials are needed to validate these findings.

[Immune checkpoint inhibitor-induced eosinophilic fasciitis: a case report and literature review].

A 58-year-old male patient with angioimmunoblastic T-cell lymphoma developed a rash and skin tightness on the face, limbs, and trunk together with joint stiffness and dysfunction after 6 months of treatment with the programmed cell death protein-1 inhibitor camrelizumab. Laboratory tests revealed progressive eosinophilia over 6 months, with the eosinophil count increasing from 0.07×109/L to 3.3×109/L. Magnetic resonance imaging showed thickened skin of both forearms, while T2-weighted imaging showed markedly increased signal intensity within the myofascia. Skin biopsy of the right forearm showed thickened and fibrosed fascia and infiltration of inflammatory cells, including lymphocytes, plasma cells, and eosinophils. The patient was diagnosed with immune checkpoint inhibitor (ICI)-induced eosinophilic fasciitis (EF). After beginning treatment with methylprednisolone (40 mg daily), methotrexate (10 mg/week), and baricitinib (4 mg daily), his symptoms of skin tightness and joint dysfunction significantly improved within 1 month, and his peripheral blood eosinophil count decreased to 0.17×109/L. ICI-induced EF is a rare immune-related adverse reaction. To date, only 20 cases have been reported in published foreign literature, and their clinical characteristics are summarized here. The time from ICI treatment to EF was 12 (8,15) months, and the main clinical manifestations included skin involvement (n=19), joint dysfunction (n=11), myalgia/muscle weakness (n=9), and peripheral eosinophilia (n=16). After treatment, the clinical symptoms of EF improved in 17 patients, and eosinophil counts returned to normal after 3 (1,8) months. EF is a dysfunctional adverse response to ICI therapy. Tumor patients undergoing immunotherapy should be monitored for symptoms of EF. Early treatment is essential for preventing complications.

Morphological classification and measurement of the glenoid cavity using three-dimensional reconstruction in a Chinese population.

BACKGROUND: The purpose of this study was to examine the various shapes and record the morphometric data of the glenoid cavity in a Chinese population. MATERIALS AND METHODS: A total of 501 scapulae, 247 left and 254 right, were analysed. We classified the shape of the glenoid cavity as type I (pear-shaped), type II (oval-shaped), type III (teardrop-shaped), type IV (calabash-shaped) or type V (inverted comma-shaped). Four defined parameters, the superior-inferior glenoid diameter (AB), upper anterior-posterior glenoid diameter (CD), lower anterior-posterior glenoid diameter (EF) and glenoid index (GI), were measured, and five shapes were classified via three-dimensional reconstruction. RESULTS: The mean AB, CD, EF and GI values of the glenoid were 3.51 ± 0.41 cm, 1.95 ± 0.28 cm, 2.60 ± 0.34 cm, and 1.35 ± 0.12 cm, respectively. The AB value of type II glenoid cavities was significantly smaller than that of type I and III glenoid cavities (p < 0.05), but the GI value of type II glenoid cavities was larger than that of type III cavities (p < 0.05). The CD value showed a difference between type I and type III glenoid cavities (p < 0.05). For the EF parameter, the values of type III glenoid cavities were significantly larger than those of type I and II glenoid cavities (p < 0.05). CONCLUSIONS: Measuring and observing the variety of shapes and sizes of the glenoid cavity in Chinese people is conducive to for better understand its morphological features. This information can also guide surgeons in the design and selection of suitable prostheses for total shoulder arthroplasty in the Chinese population in order to reduce postoperative complications.

Pejotização and implications for nursing work in Brazil: repercussions of neoliberalism / Pejotização e implicaciones para el trabajo de enfermería en Brasil: repercusiones del neoliberalismo / Pejotização e as implicações para o trabalho de enfermagem no Brasil: repercussões do neoliberalismo

ABSTRACT Objective: To analyze pejotização in the context of nursing work and the respective implications for the protection and health of these professionals. Method: Documentary study, which had news, resolutions, and recommendations issued by the Federal Nursing Council and the Regional Nursing Councils as data collection source, which underwent lexical analysis, based on data processing using the software Iramuteq. Results: Six news items were captured for analysis. The similitude analysis was built with 40 active forms and six discussion centers were generated, with the most expressive lexicons in each of these being outsourcing, economic, pejotização, deputy, Federal Nursing Council, Bill of Law. Conclusion: In the quest to increase capital based on neoliberal ideas, strategies are produced that put the workers' and users' health and safety at risk. Pejotização leads to loss of labor rights, as it deprives the worker of consolidated labor achievements, such as the 13th salary, paid vacations, sick leave and, above all, insecurities are generated in relation to the future, with few guarantees, causing negative impacts on these workers' health.

RESUMEN Objetivo: Analizar la pejotização en el contexto del trabajo de enfermería y las respectivas implicaciones para la protección y la salud de estos profesionales. Método: Estudio documental, que tuvo como fuente de recolección de datos noticias, resoluciones y recomendaciones emitidas por el Consejo Federal de Enfermería y los Consejos Regionales de Enfermería y sometidos a análisis del léxico, a partir del procesamiento de datos utilizando el software Iramuteq. Resultados: Se capturaron seis noticias para análisis. El análisis de similitud se construyó con 40 formas activas y se generaron seis núcleos de discusión, con los léxicos más expresivos en cada uno de estos siendo terceirización, económico, pejotização, diputado, Consejo Federal de Enfermería, Proyecto de Ley. Conclusión: En la búsqueda por aumentar el capital y las ideas neoliberales se producen estrategias que ponen en riesgo la salud y seguridad de los trabajadores y usuarios. Se pierden los derechos laborales, a través de la pejotização, negándose al trabajador conquistas laborales consolidadas, como el salario 13, vacaciones pagadas, bajas por enfermedad y, sobre todo, se generan inseguridades en relación al futuro, con pocas garantías, provocando impactos negativos. sobre la salud de estos trabajadores.

RESUMO Objetivo: Analisar a pejotização no contexto do trabalho de enfermagem e as respectivas implicações para proteção e saúde desses profissionais. Método: estudo documental, que teve como fonte de coleta de dados notícias, resoluções e recomendações veiculadas pelo Conselho Federal de Enfermagem e pelos Conselhos Regionais de Enfermagem e submetidas à análise lexical, a partir do processamento dos dados pelo software Iramuteq. Resultados: Captaram-se seis notícias para análise. A análise de similitude foi construída com 40 formas ativas e geraram-se seis núcleos de discussão, sendo os léxicos mais expressivos em cada um destes: terceirização, econômico, pejotização, deputado, Conselho Federal de Enfermagem, Projeto de Lei. Conclusão: Na busca por incremento do capital no ideário neoliberal, produzem-se estratégias que colocam em risco a saúde e a segurança de trabalhadores e usuários. Existe perda de direitos trabalhistas, por meio da pejotização, negando-se ao trabalhador conquistas laborais consolidadas, como 13º salário, férias remuneradas, licença por adoecimento e, sobretudo, geram-se inseguranças em relação ao futuro, com poucas garantias, ocasionando impactos negativos na saúde desses trabalhadores.

[Effect of adenovirus-mediated shRNA down-regulates SHP2 expression on the apoptosis of human hepatic stellate cells LX-2].

Objective: To investigate the effect of adenovirus-mediated short hairpin RNA (shRNA) downregulating SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) on the apoptosis of human hepatic stellate cells LX-2 cultured in vitro. Methods: The recombinant adenovirus Ad-shRNA/SHP2 carrying shRNA targeted SHP2 and expressing green fluorescent protein (GFP), and the empty control virus Ad-GFP expressing GFP were transfected into LX-2 cells cultured in vitro. Real-time fluorescence quantitative PCR was used to detect SHP2 mRNA expression in LX-2 cells. Western blot was used to detect the protein expressions of SHP2, Bax, and Bcl-2 in LX-2 cells. TUNEL and annexin-V/propidium iodide dual-labeled flow cytometry were used to detect apoptosis in LX-2 cells. Experimental group: (1) Control group: LX-2 cells were transfected with DMEM instead of adenovirus; (2) Ad-GFP group: transfected with empty virus Ad-GFP; (3) Ad-shRNA/SHP2 group: transfected with recombinant adenovirus Ad-shRNA/SHP2. The means between multiple groups were compared using a one-way ANOVA and the LSD test was used for inter group comparisons. Results: shRNA-targeted SHP2 significantly down-regulated the expression of SHP2 protein and mRNA in LX-2 cells (P < 0.05). The TUNEL and annexin-V/propidium iodide dual-labeled flow cytometry results showed that the apoptosis rate of LX-2 cells in the Ad-shRNA/SHP2 group (12.755%±1.606%, 19.340%±2.505%) (P < 0.05) was significantly higher compared to the control group (3.077%±0.731%, 9.438%±0.804%) and the Ad-GFP group (3.250%±0.851%, 8.893%±1.982%), with no statistically significant difference between the control group and the Ad-GFP group (P > 0.05). Western blot analysis of Bax and Bcl-2 protein expression in LX-2 cells of each group revealed that the Bax protein expression was significantly higher in the Ad shRNA/SHP2 group (2.493 ± 0.203) (P < 0.05) compared to the control group and Ad-GFP group (1.989 ± 0.147, 1.999 ± 0.162), with no statistically significant difference between the control group and the Ad-GFP group (P > 0.05), while the Bcl-2 protein was significantly decreased in the Ad-shRNA/SHP2 group (1.042±0.148) compared with the control group and the Ad-GFP group (1.707±0.146, 1.521±0.142), with no statistically significant difference between the control group and the Ad-GFP group (P > 0.05). Conclusions: SHP2 expression down-regulation induces apoptosis of human hepatic stellate cells LX-2 in vitro by reducing Bcl-2/Bax.

Direitos dos docentes de enfermagem na contemporaneidade: análise a partir de grupo focal / Rights of nursing teachers in the contemporany: analysis from focal group / Derechos de los profesores de enfermería en la contemporánea: análisis desde un grupo focal

Objetivo: verificar a percepção dos docentes universitários de enfermagem acerca dos seus direitos laborais e discutir tais direitos na contemporaneidade. Método: pesquisa descritiva e exploratória de abordagem qualitativa realizada em universidades públicas situadas no município do Rio de janeiro. Os participantes do estudo foram 14 docentes de enfermagem lotados em duas universidades públicas. Para a coleta de dados foi utilizado o grupo focal e os dados foram analisados à luz da técnica de análise de conteúdo. Resultados: emergiram três categorias: os direitos do docente de enfermagem nas universidades públicas no contexto neoliberal; educação como direito de todos para o desenvolvimento do Brasil; e direitos laborais sob a ótica dos docentes de enfermagem: respeito ao contrato de trabalho. Conclusão: destaca-se a necessidade de respeito aos direitos humanos, para a promoção da qualidade de vida no contexto do trabalho do docente

Objective: to verify the perception of university nursing professors about their labor rights and to discuss these rights in contemporary times. Method: descriptive and exploratory research with a qualitative approach carried out in public universities located in the city of Rio de Janeiro. Study participants were 14 nursing professors working at two public universities. For data collection, the focus group was used and the data were analyzed in the light of the content analysis technique. Results: three categories emerged: the rights of nursing professors in public universities in the neoliberal context; education as a right for all for the development of Brazil; and labor rights from the perspective of nursing professors: respect for the employment contract. Conclusion: the need to respect human rights is highlighted, in order to promote quality of life in the context of the teacher's work

Objetivo: verificar la percepción de los profesores universitarios de enfermería sobre sus derechos laborales y discutir esos derechos en la contemporaneidad. Método: investigación descriptiva y exploratoria con enfoque cualitativo realizada en universidades públicas ubicadas en la ciudad de Río de Janeiro. Los participantes del estudio fueron 14 profesores de enfermería que trabajaban en dos universidades públicas. Para la recolección de datos se utilizó el grupo focal y los datos fueron analizados a la luz de la técnica de análisis de contenido. Resultados: surgieron tres categorías: los derechos de los profesores de enfermería en las universidades públicas en el contexto neoliberal; la educación como derecho de todos para el desarrollo de Brasil; y derechos laborales en la perspectiva de los profesores de enfermería: respeto al contrato de trabajo. Conclusión: se destaca la necesidad de respetar los derechos humanos, con el fin de promover la calidad de vida en el contexto del trabajo docente

[Standardized diagnosis and treatment of undifferentiated connective tissue disease and mixed connective tissue disease].

Undifferentiated connective tissue disease (CTD) usually refers to patients who are presented with certain symptoms and signs related to CTD, and positive serological evidence of autoimmune diseases but don't fulfill any of the classification criteria for a certain CTD. Mixed CTD refers to patients who are presented with one or more clinical manifestations such as hand swelling, synovitis, myositis, Raynaud's phenomenon, and acrosclerosis. Patients with mixed CTD always have high-titer anti-nuclear antibodies (ANA) of speckled pattern and high-titer anti-U1 ribonuclear protein (RNP) antibody in serum, while with negative anti-Sm antibody. The update of diagnosis and treatment of undifferentiated CTD and mixed CTD lags behind other established CTD. There is a lack of evidence from randomized controlled trials or guidelines/recommendations on the treatment of undifferentiated CTD or mixed CTD. At present, the conventional therapy is mainly adopted according to the specific clinical manifestations of the disease. The standardized diagnosis and treatment of undifferentiated CTD and mixed CTD were drafted by the Chinese Rheumatology Association based on the previous guidelines and the progress of available evidence, so as to improve the management of these patients in China.

[Progress in platelets and chronic obstructive pulmonary disease].

Platelets-related pathophysiological mechanism and clinical research is one of the research hot topics in chronic obstructive pulmonary disease (COPD) at home and abroad. Increasing evidence has proved the association between thrombocytosis and COPD. Platelets activation interacts with COPD. Antiplatelet therapy has been shown to have significant effects on both short-term and long-term outcomes in COPD. Platelets inhibition may be an emerging therapeutic target for COPD, and antiplatelet therapy is expected to become an inexpensive and effective treatment for COPD. This article reviewed the research progress in platelets and COPD.

[Summary of the 17th Chinese Symposium on Burn Medicine and the 2022 Congress of Burn Medicine Branch of China International Exchange and Promotion Association for Medical and Healthcare, and the 12th Academic Conference on Burn and Plastic Surgery in Five Provinces and One City in Southwest China].

The 17th Chinese Symposium on Burn Medicine and the 2022 Congress of Burn Medicine Branch of China International Exchange and Promotion Association for Medical and Healthcare, and the 12th Academic Conference on Burn and Plastic Surgery in Five Provinces and One City in Southwest China was successfully held in green city Nanning, from August 25th to 27th, 2022. The conference theme was "Burn treatment and wound repair", received nearly 200 submissions, nearly 1 100 online and offline registered delegates, and nearly 300 offline attendees. The meetings were held in one main venue and three branch venues, with combination of speaking offline and live and recorded broadcast, as well as whole process synchronous live broadcasting. During the meeting, key issues about burn treatment and wound repair were discussed, with warm academic atmosphere.

[Two-dimensional equivalent mechanical modeling and finite element analysis of normal female pelvic floor system].

Objective: To construct the geometric model of the pelvic floor by a two-dimensional equivalent mechanics method, and to explore the effect of the shape and position of pelvic floor organs and tissues on the biomechanical properties of the pelvic floor under different abdominal pressure. Methods: A 28-year-old healthy and symmetrical married infertile female volunteer was included. The pelvic floor tissue was scanned in the supine position using a 3.0T magnetic resonance scanner (Philips Company, Holland). Based on the method of magnetic resonance imaging (MRI) two-dimensional parameter measurement and computer aided design, the geometric model and finite element model of the female pelvic floor were established, and the biomechanical characteristics of the pelvic floor support system under different abdominal pressure were analyzed. Results: In this study, four different working conditions of the pelvic floor force were simulated under 60, 99, 168, and 208 cmH2O (1 cmH2O=0.098 kPa) abdominal pressure loads. The trend was as follows: under the abdominal pressure load, the retrograde flexion of the uterus occurred, the cervical, the middle and upper vaginal segment and the levator anus muscle had the characteristic change of mechanical axial direction pointing to the sacrum and coccyx, and the deformation of the levator anus muscle in the horizontal direction was greater than that in the vertical direction. With the increase of the abdominal pressure, the maximum stress values of the pelvic floor whole system of healthy subjects under four different working conditions were 0.194 3, 0.389 6, 0.557 1, and 0.627 5 MPa, respectively, and the maximum displacement values were 10, 14, 21 and 25 mm, respectively. The maximum stress values of the cervical and vaginal middle and upper segment were 0.111 7, 0.161 8, 0.250 6, and 0.304 1 MPa, respectively, and the maximum displacement values were 3, 6, 9, and 11 mm, respectively. The maximum stress of the perineal body was 0.063 4, 0.119 6, 0.235 2, and 0.288 0 MPa, and the maximum displacement was 1, 2, 4, and 5 mm. The maximum stress values of the levator anus muscle were 0.194 3, 0.389 6, 0.557 1, and 0.627 5 MPa, and the maximum displacement values were 2, 4, 7, and 8 mm, respectively. The maximum stress and maximum displacement of pelvic organs increased with the increase of the abdominal pressure under different working conditions. The stress axial relationship of normal female pelvic floor was that the middle and upper segment of uterus and vagina mainly acted on the sacrococcyx and the levator anus muscle, and the lower vaginal segment acts on the perineal body. Conclusions: The two-dimensional equivalent mechanical modeling and finite element analysis of the female pelvic floor system can accurately reflect the biomechanical characteristics of the female pelvic floor, and the resultant stress direction of the pelvic organs points to the sacrum and coccyx. The sacrum and coccyx, levator anus and perineal body play important stress supporting roles in the pelvic floor system.