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Chem Commun (Camb) ; 60(47): 6007-6010, 2024 Jun 06.
Article in English | MEDLINE | ID: mdl-38787679

ABSTRACT

The enantioselective de novo synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors were measured.


Subject(s)
Morphinans , Stereoisomerism , Morphinans/chemistry , Morphinans/chemical synthesis , Naltrexone/analogs & derivatives , Naltrexone/chemistry , Naltrexone/chemical synthesis , Molecular Structure , Narcotic Antagonists/chemical synthesis , Receptors, Opioid/metabolism
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