[Socio-economic aspects of epidemiology of helicobateriosis].

There are considered special social and economic aspects of the epidemiology of Helicobacter pylori. These aspects acquired the particular importance for the last time due to the fact that the provision of the people with pure water has been becoming the focus of the attention of geopolitical and socio-economic interests in a number of countries. The availability ofpure drinking water serves a marker of the socio-economic state of the territory and the population living there. In Russia where different climatic conditions are deposited by considerable regional differences in the conditions of communal services caused both by various level of the socio-economic development of the territory, the supplementation with pure drinking water serves as the social determinant of the ecological conditions of the population's life. This particularly has impact on the unfeasible technical state of the water distribution systems, microorganism ecology of which can substantially affect public health. The performed by authors a specialized screening ofpresented at the official web site of the joint-stock company «Mosvodokanal¼ current data concerning the quality of drinking water consumed by 2500 Moscovites, tested for the Helicobacter pylori infection revealed no deviations from the sanitary standards in the water received by the consumers. Along with that, the comparison of the map documents of the distribution of the Helicobacter pylori infection in Moscow with the distribution of citizens' complaints of the decline of the quality of tap water has revealed a territorial fastening of the high values of the population infection rate of n^ylori and the urban sites with the greatest number of complaints. In the microbial ecology of water-distribution systems there are tightly aligned problems of their epidemiological safety, technical state and economic damage caused by corrosion as a result of microbiotic activity. In contrast to acute bacterial and viral infections which are deemed of the greatest importance when assessing the sanitary condition of water sources and water-distribution systems, the consequences of infection with H. pylori may not be manifestedfor a long time but some years later they may be manifested as serious chronic diseases (from gastritis to adenocarcinoma of the stomach and a wide range of extraintestinal pathologies), which causes great social and economic losses. Thus, the socio-economic aspect of the epidemiology of helicobacteriosis includes at least two components: the technic - the maintenance of the feasible technic and sanitary state of the water distribution systems and the medico-social - expenditures for screening and treatment of infected patients. In total they are an inseparable part of the prevention of socially-important diseases in the public health system.

[Prevention of pyloric H. pylori infection is the actual problem of modern preventive health care].

In the article there are presented data on the high prevalence of Helicobacter pylori (H. pylori) infection in Russia and its consequences, including the development of gastric cancer. There is presented the evidence of possible transmission of H. pylori with water previously underestimated. There is substantiated the necessity of preventing infection, which should include the informing of the population, compliance with hygiene standards and widespread availability of safe water.

[The study of spatial distribution of Helicobacter pylori infection rate in able-bodied population of Moscow in the course of medical examination of the manufacturing contingents].

UNLABELLED: Numerous studies have shown that Helicobacter pylori (H. pylori) is a leading etiologic factor in the development of chronic atrophic gastritis, one gastric ulcer and duodenal ulcer and gastric cancer. Effective prevention of gastroduodenal pathology requires the right information about its prevalence in the population and risk factors. The most reliable information can be obtained during medical examination of the able-bodied population, which provides in-depth clinical examination of contingents with the identification of asymptomatic pathology, detection of risk groups, the substantiation ofprophylactic measures and tracking their efficacy. MATERIAL AND METHODS: During the clinical examination of the manufacturing contingents there was performed a study of the presence of infection Helicobacter pylori (H. pylori) in 2414 people aged 19 to 74 years. For more details on the presence of gastroduodenal pathology 991 people were examined with the use of clinical methods and interviews. The aggregation of information presented in the form of estimates for its geocoding and mapping has been made. Cluster analysis was performed. RESULTS: H. pylori infection was diagnosed in 2,182 people accounting for 90.4% out of 2414 examined cases. Infections occurred equally in males--91.7% and females--89.6%. The risk of development of gastroduodenal pathology in individuals infected with H. pylori is 4.4 times greater than the risk in seronegative individuals (95%, confidence interval 1.9-6.4). Cluster analysis revealed a statistically significant clusters for the strata with a prevalence of 100% (X2 = 45.5204) and below 50% of infection rate (X2 = 7.36). It is in prospect to analyze in more detail the data relating to these areas in order to identify the factors contributing to the different degree of infection rate of residents, including the assessment of drinking water.

[To the problem of evaluation of public health: screening for gastroduodenal pathology on the example of atrophic gastritis in mass medical examination of the population].

Assessment of health status of the population - the most important issue in preventive medicine. The objective of this work - to determine the possibility of nonendoscopic screening for gastroduodenal pathology, by the example of atrophic gastritis, in mass medical examinations of working residents in Moscow. Minimally invasive diagnostic test system GastroPanel ("Biohit", Finland) has been used. It allows with the ELISA method to determine both serum indicators of the function of the stomach -pepsinogen 1, gastrin 17 and the presence of H. pylori infection. 758 persons have been examined. The performed study confirms the possibility with the use of a set of mentioned indicators to identify individuals suspected for the presence of gastroduodenal disorders, especially atrophic gastritis, recognized as a precancerous condition. The use in preventive medicine complex diagnostic system, firstly, will make assessment of the health of the population more correct, increase the effectiveness of preventive measures and quality of life, and secondly, will contribute to the diagnosis of diseases of the stomach and duodenum in the early stages.

[Epidemiological characteristics of Helicobacter pylori infection in Moscow].

The authors studied the prevalence and a number of epidemiological features of Helicobacter pylori (Hp) infection in Moscow. A prophylactic medical examination revealed the infection in 863 working residents of the megapolis. A mini-invasive study was used. Enzyme immunoassay was carried out to determine serum IgG antibodies against Hp. The authors' questionnaire was used in 634 interviews. There was an extremely high incidence (88%) of Hp infection. The prevalence of the infection was found to be related to age, social status (social position, educational level), living conditions (shared or hostel habitation, no sewerage system), contact with waste waters. No association was found between the rate of the infection and the examinees' gender, the intake of raw Moscow tap drinking water, and the contact with domestic animals. Moscow was rated among the cities with a high prevalence of Hp infection. The study revealed a number of epidemiological features of the infection in the megapolis, a knowledge of which is required to elaborate measures for its prophylaxis and the prevention of its associated diseases.

[Morphometrics and immunohistochemical characteristics of chronic gastroduodenitis in adolescents]. / Morfometricheskaia i immunogistokhimicheskaia kharakteristika khronicheskogo gastroduodenita u podrostkov.

Mucous membrane of the antral region of the stomach and that of duodenum were studied in 36 teenagers, 21 of them had erosions revealed endoscopically and histologically. Morphometric indices of the inflammation were more pronounced when erosions were present; the latter did not influence the local production of IgA, IgM and IgG. The content of IgG was particularly high. Contamination with Helicobacter pylori was found in all cases and was more pronounced in erosive gastroduodenitis. High frequency of lymphoid follicles formation was found, particularly in the antrum.