[Beta 2-microglobulin and a test using 169 Yb-DTPA in evaluating glomerular filtration and reabsorption of protein in gynecologic cancer patients]. / Beta 2-microglobulin i proba s 169Yb-DTPK v otsenke klubochkovoi filtratsii i reabsorbtsii belka u onkoginekologicheskikh bol'nykh.

Radionuclide investigation (a test with 169Yb-DTPA) and radioimmunoassay determination of the concentration of beta 2-MG in the blood serum and urine were performed to study glomerular filtration and protein reabsorption in patients with myoma (57) and uterine body cancer (51) before operation, on the 1st, 3rd, 5th and 14th days of the postoperative period, and 6-12 mos. after operation. At the same time 24 healthy women (controls) were investigated. The greatest changes of glomerular filtration and protein reabsorption in the patients of the study group were shown to develop on the 5th day after operation. There was parallelism of the results of radionuclide investigation and the radioimmunoassay with beta 2-MG therefore the latter can be recommended for the diagnosis of renal dysfunction in the early postoperative period.

[Influence of the pathogenetic variant of uterine cancer on the dynamics of prolactin secretion in the early and late postoperative periods]. / Vliianie patogeneticheskogo varianta raka tela matki na dinamiku sekretsii prolaktina v rannem i pozdnem posleoperatsionnom periode.

In early postoperative period, patients with uterine carcinoma of pathogenetic types I and II developed hyperprolactinemia with similar frequency. However, elevation of prolactin concentration was found to vary with pathogenetic type. For type I endometrial carcinoma, prolactin level on postoperative days 1-5 was twice those registered in type II tumor. Later, prolactin levels returned to normal.

[Radionuclide study of the function of the kidneys and their hormonal regulation in cancer of the uterus]. / Radionuklidnoe issledovanie funktsii pochek i ikh gormonal'naia reguliatsiia pri rake tela matki.

Methods of radionuclide renography with 131I-hippuran and a radioimmunoassay determining plasma renin activity, the level of aldosterone and cortisol were employed to study function of the kidneys and the system of the hormonal regulation of renal functions in 40 uterine body cancer patients in the time course of surgical treatment. A group of patients without a history of renal diseases was examined prior to operation 1, 3, 5, 14 days and 6-12 mos after extirpation of the uterus with appendages. It was established that the patients had basal intrarenal urodynamic disturbances and elevated renin activity. Unfavorable effects of surgical intervention occurred more frequently on the 1st day in the postoperative period when the presence of latent renal insufficiency could be detected by radionuclide methods. The process of renal function recovery was observed however it was determined by the level of preoperative disorders and did not reach the normal. There was correlation between an increase in renin activity and disturbances in intrarenal urodynamics in surgical treatment of uterine body cancer patients.

[Dynamic scintigraphy of the liver using 131I-rose bengal and the bile acid content of the blood following gastrectomy for cancer]. / Dinamicheskaia stsintigrafiia pecheni s 131I-bengal'skim rozovym i soderzhanie zhelchnykh kislot v krovi posle gastréktomii po povodu raka.

Liver function was studied in 84 patients with operable stomach cancer prior to and at varying times after gastrectomy using dynamic scintigraphy with 131I-rose bengal and determination by a radioimmunoassay of bile acids in the peripheral blood. A group of patients without signs of focal lesion of the liver and a history of its diseases was examined. It was shown that disorders of hepatocytic function took place before the operation. After gastrectomy the disorders were accompanied by considerable retardation of the basal secretion of bile into the intestine. At the same time an increase in the concentration of bile acids in the peripheral blood above the discriminant level of healthy persons, i.e. over 0.5 mg/l was observed. Disorders of liver function were of long duration and persistent over 1 year after gastrectomy.

[Hormonal status of patients with uterine cancer during surgical treatment]. / Izuchenie gormonal'nogo statusa bol'nykh rakom tela matki pri khirurgicheskom lechenii.

A radioimmunoassay was conducted in the pituitary-ovary and pituitary-adrenals systems in 37 cases of endometrial carcinoma before treatment and 1, 3, 5 and 14 days after extirpation of the uterus and adnexa. The levels of follicle-stimulating (FSH) and luteinizing (LH) hormones of the pituitary, prolactin, ACTH, estradiol, progesterone, testosterone, cortisol and aldosterone were studied. Such disturbances as decreased production of FSH, LH, progesterone and testosterone were observed before operation. Surgery was followed by a considerable rise in prolactin production and basal levels of FSH and LH, a decrease in estradiol, progesterone and testosterone concentrations and was accompanied by a sizeable release of cortisol and aldosterone.

[Experience in using radionuclide study methods in the gynecological cancer clinic]. / Opyt primeneniia radionuklidnykh metodov issledovaniia v onkoginekologicheskoi klinike.

The report deals with a retrospective analysis of applications of different in vivo and in vitro methods of radionuclide studies (1863) in patients with gynecological tumors in 1972-1985. The said methods were employed for making primary diagnosis, assessing tumor extension as well as for evaluating the effects of tumor growth and the efficacy of radiation and surgical treatment. Apart from offering considerable advantages as diagnostic procedures, radionuclide studies may be used in planning treatment modalities and schemes of rehabilitation of cancer patients. The results also suggest a wider application of nuclear procedures in addressing the diagnostic problems of practice of oncology.

[Radionuclide studies of the digestive organs during radiotherapy of cervix cancer]. / Radionuklidnye issledovaniia organov pishchevareniia pri luchevoi terapii raka sheiki matki.

A radionuclide study of liver, small intestine function and a radioimmunoassay to determine the level of insulin, C-peptide and gastrin in the blood were performed in 177 patients with cervical cancer before and during radiation therapy and in 77 healthy women. Combined radiotherapy of cervical cancer was shown to result in disorder of absorptive-excretory function of the liver, disturbed fat assimilation in the small intestine and a decrease in gastrin production. Hyperfunction of the pancreas endocrine apparatus was noted in the cervical cancer patients, and radiation therapy caused the suppression of insulin production.

[Function of the hypothalamo-pituitary-ovarian system during radiotherapy of patients with cervical cancer]. / Funktsiia sistemy gipotalamus-gipofiz-iaichniki pri luchevom lechenii raka sheiki matki.

Radioimmunoassay of the hypothalamic-hypophyseal-ovarian interrelationships was performed in 87 patients with cervical cancer and 37 practically healthy women. The patients were examined before concomitant radiation therapy, after administration of the half dose to the focus, immediately after irradiation and 3-12 mos. and 2-5 yrs. after it. The basal level of the follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol as well as their response to the administration of the releasing factor of the hypothalamus (luliberin) were studied. Some disorders that manifested themselves in the decreased level of estradiol, were established in the patients with cervical cancer even before irradiation. Concomitant radiation therapy resulted in pronounced changes in the activities of the hypothalamic-hypophyseal-ovarian system that manifested themselves in the lowered rate of LH increment in response to the administration of luliberin and the absence of estradiol response to the load. These changes persisted long after the termination of concomitant radiation therapy.

[The effect of combined radiotherapy on blood levels of ACTH, cortisol and aldosterone in cervical cancer]. / Vliianie sochetannoi luchevoi terapii na soderzhanie AKTG, kortizola i al'dosterona v syvorotke krovi pri rake sheiki matki.

Blood-ACTH, cortisol and aldosterone levels in patients with cancer of the uterine cervix were measured radioimmunologically prior to complex radiotherapy, following a half-dose exposure of tumor focus and immediately on completion of the treatment course. Patients showed a rise in cortisol and aldosterone levels and a slight increase in ACTH. Radiation therapy inhibited production of cortisol and aldosterone matched by a rise in ACTH output.

[Scintigraphy of the liver with 131-I-bengal rose and determination of ferritin in the blood during combined radiotherapy of cancer of the cervix]. / Stsintigrafiia pecheni s 131-I-bengal'skim rozovym i opredelenie ferritina v krovi pri sochetanno-luchevom lechenii raka sheiki matki.

Altogether 117 patients with cervical cancer on combined radiation therapy were examined. They were examined before the start of radiation therapy, after a focal dose of 35-40 Gy, immediately after the termination of irradiation and in 3-12 mos. after treatment. Using a method of dynamic computerized scintigraphy with 131I-Bengal rose absorptive-excretory function of the liver was studied; the level of ferritin was determined too. Combined radiation therapy was shown to cause hepatic disorders that manifest themselves in the suppression of absorptive-excretory function of the liver and a decreased level of ferritin. The most noticeable changes were recorded in the patients examined immediately after the termination of irradiation. Results of both methods show good correlation.

[Correlation of insulin and C-peptide secretion in oncological patients]. / Sootnoshenie sekretsii insulina i C-peptida u onkologicheskikh bol'nykh.

Insulin and C-peptide levels were studied with a radioimmunoassay in the peripheral blood serum of 44 patients with gastric and cervical cancer and 22 healthy persons. Hyperfunction of the pancreatic insular apparatus was shown in cancer patients which was expressed in a statistically significant increase in the C-peptide level. In gastric cancer patients hyperfunction of the insular apparatus was accompanied by hypoinsulinemia, and in cervical cancer patients by hormoinsulinemia. However an analysis has shown that the ratio insulin/C-peptide in gastric and cervical cancer patients was about the same and significantly lower than the control. A conclusion has been made that in spite of difference in the initial insulin concentration, the same phenomenon--acceleration of the metabolic clearance of insulin--occurs in patients with cancer of the above sites. As a result of treatment irrespective of its modality the reverse development of changes revealed before treatment took place. The C-peptide level decreased, the ratio insulin/C-peptide increased, i.e. hyperfunction of the insular apparatus disappeared and the metabolic clearance of insulin slowed down.

[Levels of growth hormone, prolactin, cortisone, aldosterone and insulin in the blood of patients with stomach cancer, before and after gastrectomy]. / Uroven' gormona rosta, prolaktina, kortizola, al'dosterona i insulina v krovi bol'nykh rakom zheludka do i posle gastréktomii.

The basal blood levels of certain hormones were determined by radioimmunologic assay in 130 patients with stomach cancer before surgery and at different periods (10-30 days, up to 1 year, 1-5 years and over 5 years) after gastrectomy. Increased levels of growth hormone and prolactin were matched by a lowered concentration of insulin. Elevated levels of cortisol and aldosterone were observed in stage IV. Within the first 10-30 days after operation, hormonal profile (except insulin) showed a tendency to normalization. At later stages, hormone levels showed various changes.