ABSTRACT
A case of mesoblastic nephroma in a 14-month-old girl who developed consecutive metastases in the lung and the heart is presented. This tumor is considered to be benign and cured by surgery only. Recurrent cases are extremely rare and usually related to unclear surgical margins. Metastatic mesoblastic nephroma has been previously described in only two cases. The present case highlights a new, previously undescribed feature--the ability to metastasize to sites other than lung.
Subject(s)
Heart Neoplasms/secondary , Kidney Neoplasms/pathology , Lung Neoplasms/secondary , Wilms Tumor/pathology , Combined Modality Therapy , Female , Humans , Infant , Kidney Neoplasms/therapy , Wilms Tumor/therapyABSTRACT
One type of non-A non-B hepatitis (NANBH) is caused by hepatitis C virus (HCV), and is mostly transmitted through blood transfusion or its components. The prevalence of NANBH among post transfusion hepatitis (PTH) in Western countries is around 90-95%. After Chiron had identified the viral protein which caused parenteral NANBH or HCV, it became possible to detect the antibody for HCV as a sign of its transmission. In Indonesia, the usage of blood and its components gradually increased every year. Since 1985, all blood components from the Indonesian Red Cross were screened against hepatitis B virus (HBV), and it was found that most of the post-transfusion hepatitis were caused by HCV. In this study, the prevalence of the HCV antibody in blood donors was 3 out of 193 (1.6%) using the ELISA method (Ortho).
Subject(s)
Blood Donors/statistics & numerical data , Hepatitis C/epidemiology , Enzyme-Linked Immunosorbent Assay , Hepatitis C/transmission , Humans , Indonesia/epidemiology , Prevalence , Transfusion Reaction , Urban HealthABSTRACT
A total of 72 chromosomes from 36 Indonesian patients, 23 with beta-thalassemia major and 13 with Hb E-beta-thalassemia, were analyzed by specific oligonucleotide hybridization after DNA amplification. Thirteen had the beta E mutation (codon 26 GAG----AAG). Of the 59-beta-thalassemic chromosomes, 32 were of the variant IVS-1 nt5 (G----C). Seven had the mutation IVS-2 nt654 (C----T), one had the mutation codon 41/42 (deletion CTTT), and one had the mutation codon 17 (AAG----TAG). Another six with the mutation IVS-1 nt1 (G----T), one with the mutation IVS-1 nt1 (G----A), four with the mutation codon 15 (TGG----TAG), one with a mutation codon 30 (AGG----ACG), and one with a mutation codon 35 (deletion C) were first identified by direct sequencing of a patient's genomic DNA followed by further hybridizing other patients' DNA with the appropriate oligonucleotide probes. Five did not carry the common mutations previously described in Asian populations. The four most prevalent mutations encountered made up 83% of the total number of beta-thalassemic chromosomes studied. The most common mutation, IVS-1 nt5 (G----C), was mostly associated with two different haplotypes.
Subject(s)
Genetic Linkage , Globins/genetics , Haplotypes , Mutation , Thalassemia/genetics , Blotting, Southern , DNA/genetics , Gene Amplification , Humans , Indonesia , Oligonucleotide ProbesABSTRACT
The prevalences of hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs) were determined in blood donors and transfusion recipients in Jakarta, Indonesia. In blood donors the prevalence of HBsAg was 10% while anti-HBs was 43%. In transfusion recipients the prevalence of HBsAg and anti-HBs was 67%. The prevalence of susceptible recipients or those without detectable HBsAg or anti-HBs was 33%. Thus, the probability that a susceptible recipient would receive HBsAg from a blood donor was calculated at 3.3%. Published data from other studies were used to estimate the risk of clinical post transfusion hepatitis in Jakarta at between 0% and 2%.
