ABSTRACT
Los síndromes crioglobulinémicos comprenden un conjunto de manifestaciones que se encuentran en diversas enfermedades y que comparten un mismo mecanismo fisiopatológico: el depósito de crioglobulinas en lechos vasculares. La presencia de crioglobulinas es criterio diagnóstico de estos síndromes por lo que es imprescindible su correcta detección y caracterización. El Grupo de Inmunoquímica de la Sociedad Española de Inmunología ha realizado una revisión exhaustiva clínica y metodológica, debido a la heterogeneidad técnica interlaboratorios, con el objetivo de proporcionar una herramienta útil y efectiva para el diagnóstico de síndromes crioglobulinémicos
Cryoglobulinaemic syndromes include a collection of manifestations that are found in various diseases and that share a pathophysiological mechanism: cryoglobulin deposit in vascular beds. For these syndromes, the presence of cryoglobulins is a diagnostic criterion, and their correct detection and characterisation are therefore essential. The Immunochemistry Group of the Spanish Society of Immunology conducted a comprehensive clinical and methodological review, due to the interlaboratory heterogeneity in techniques, with the objective of providing a useful and effective tool for diagnosing cryoglobulinaemic syndromes
Subject(s)
Humans , Cryoglobulins , Vasculitis/diagnosis , Laboratories/standards , SyndromeABSTRACT
Cryoglobulinaemic syndromes include a collection of manifestations that are found in various diseases and that share a pathophysiological mechanism: cryoglobulin deposit in vascular beds. For these syndromes, the presence of cryoglobulins is a diagnostic criterion, and their correct detection and characterisation are therefore essential. The Immunochemistry Group of the Spanish Society of Immunology conducted a comprehensive clinical and methodological review, due to the interlaboratory heterogeneity in techniques, with the objective of providing a useful and effective tool for diagnosing cryoglobulinaemic syndromes.
