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Med Interne ; 23(1): 63-6, 1985.
Article in English | MEDLINE | ID: mdl-2986274

ABSTRACT

Leukocyte migration inhibitory factor (LMIF) activity was tested before and after glucagon administration both in vivo and in vitro. In vivo glucagon 1 mg i.v. vs saline administration inhibited LMIF production by T lymphocytes in 85.21% patients (p less than 0.01). In vitro glucagon in physiologic (125 pg/ml) and pharmacologic (50 ng/ml) doses increased the migration area vs PPD 250 microL (migration index 0.5127 vs 0.3210; p less than 0.05). These results show a significant inhibitory effect of glucagon upon LMIF activity. We suggest that glucagon acts by enhancement of the intralymphocytic cAMP/cGMP ratio (cyclic adenosine monophosphate/cyclic guanosine monophosphate).


Subject(s)
Glucagon/pharmacology , Leukocyte Migration-Inhibitory Factors/antagonists & inhibitors , Lymphokines/antagonists & inhibitors , Adult , Aged , Cyclic AMP/analysis , Cyclic GMP/analysis , Female , Humans , Immunity/drug effects , Lymphocytes/analysis , Male , Middle Aged
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