ABSTRACT
Obtaining a sustainable drug delivery system is a challenging issue in biomedical science. This became even more important in the wound regeneration process due to its long treatment process. In this study, the calcium alginate (CaAlg) hydrogel is coated on the surface of polycaprolactone (PCL)/gelatin (Gel) nanofibers containing coconut oil (CO) using the impregnation method. The physical, chemical, and morphological properties of produced samples are investigated using different characterization techniques to verify the influence of hydrogel. Water contact angle, swelling ratio, and water vapor permeability measurements are used to evaluate the effect of hydrogel on the hydrophilicity of the proposed system. The cell viability test showed that the nanocomposite hydrogel is biocompatible and could improve wound healing. According to drug release studies, hydrogel addition to the nanofiber system plays an essential role in controlling CO release rate in the first 250 h. In vivo studies also indicated faster skin regeneration.
