ABSTRACT
Purpose: Despite the global introduction of physical literacy in recent years, a lack of a comprehensive physical literacy tool is still evident in adolescents. This study was conducted to design and perform psychometric evaluation of self-assessment adolescent physical literacy questionnaire in the Iranian sample. Methods: A mixed research method, including 3 phases, was used on 836 adolescents in the age range of 12-18 years old. A questionnaire with 59 items was designed based on the qualitative stage, refined during the validity and reliability stages, and finally, formed a questionnaire with 25 items. Results: The exploratory factor analysis showed 3 factors with an explanation of 59.5% of the total variance, and the results of confirmatory factor analysis confirmed the 3-factor model. Results also showed good internal consistency (α = 0.951), retest reliability (0.981-0.837), and concurrent validity of the questionnaire with the PPLI instrument (0.680-0.790). Conclusion: The results showed good validity and reliability of the Adolescent Physical Literacy Questionnaire (APLQ) with 3 dimensions. Therefore, it can be a suitable tool to assess adolescent physical literacy. Supplementary Information: The online version contains supplementary material available at 10.1007/s11332-021-00818-8.
ABSTRACT
Silica nanoparticles can be potentially considered the carriers of controlled drug systems. In this research, non-steroidal anti-inflammatory drugs were used. Diclofenac sodium and piroxicam were loaded on the considered nanosilica using solvent evaporation method. To prove drug encapsulation on the nanosilica and its rate, infrared spectroscopy, X-ray diffraction, and BET were used, and after proving the existence of the drug in the nanosilica matrix and determining the amount of loading, dissolution test was performed in an environment similar to that of stomach and intestine in terms of pH. Drug loading percentage showed that over 90% of drugs were loaded on nanosilica. Dissolution tests in stomach pH environment showed the control samples (drug without SBA-15) released considerable amount of drugs (about 90%) within first 15 min, when it was about 10-20% for the matrixes. Furthermore, release rate of drugs from matrixes has shown slower rate in comparison with control samples. It was indicated nanosilica has the ability of retaining the drugs in acidic pH and prevented their release. Furthermore, the drugs were released in a controlled manner in small intestine, which is the main absorption site.
