ABSTRACT
A 21-year-old woman developed an acute myotonic reaction while undergoing anaesthesia using succinylcholine. Examination later showed she had shoulder, neck and calf hypertrophy, bilateral symmetrical ptosis and eyelid, handgrip and percussion myotonia. Peripheral neurophysiology studies identified significant, continuous myotonic discharges in both upper and lower limbs. Genetic analysis identified a c.3917G>A (p.Gly1306Glu) mutation in the SCN4A gene, confirming a diagnosis of sodium channel myotonia. Succinylcholine and other depolarising agents can precipitate life-threatening acute myotonic reactions when given to patients with myotonia. Patients with neuromuscular disorders are at an increased risk of perioperative anaesthetic complications. We report a woman who developed an acute myotonic reaction whilst undergoing anaesthesia, in the context of an unrecognised myotonic disorder. We then discuss an approach to the diagnosis of myotonic disorders.
Subject(s)
Anesthesia , Myotonia , Myotonic Disorders , Female , Humans , Young Adult , Adult , Succinylcholine/adverse effects , Hand Strength , Myotonic Disorders/chemically induced , Myotonic Disorders/diagnosis , Myotonia/chemically induced , Myotonia/genetics , NAV1.4 Voltage-Gated Sodium Channel/geneticsABSTRACT
OBJECTIVES: We sought to determine the baseline demographic and clinical characteristics of patients with Chronic Venous Disease (CVD) across the Caribbean, and to evaluate patients' compliance to conservative therapy and the effectiveness of such therapy in reducing patients' CVD symptoms. METHOD: Patients were enrolled into the VEIN Act Program, and their demographic data, CVD symptoms (and their intensity) and CEAP C-classification was recorded at the first visit. Patients were prescribed conservative therapy, and symptom intensity and patient compliance and satisfaction evaluated at a follow-up visit. RESULTS: We enrolled 193 patients into the study, most of which (76%) were female, between 39-78 years (80%) and within the C2-C4a classes (56.1%). Pain (61.1%) and heaviness (58.5%) were the most common symptoms. Patient compliance to the prescribed treatment was relatively high for all modalities (>75%) and most patients (92.1%) were at least somewhat satisfied with their treatment. CONCLUSIONS: Patient compliance to conservative therapy for management of CVD is high across the Caribbean, and such therapy is effective in reducing intensity of CVD symptoms.
Subject(s)
Vascular Diseases , Venous Insufficiency , Chronic Disease , Conservative Treatment , Female , Humans , Male , Treatment Outcome , Vascular Diseases/drug therapy , Veins , Venous Insufficiency/drug therapySubject(s)
Hand Dermatoses/physiopathology , Hyperpigmentation/physiopathology , Vitamin B 12 Deficiency/diagnosis , Anorexia/physiopathology , Fatigue/etiology , Fatigue/physiopathology , Female , Hand Dermatoses/etiology , Hand Dermatoses/pathology , Humans , Hydroxocobalamin/therapeutic use , Hyperpigmentation/etiology , Hyperpigmentation/pathology , Hypesthesia/etiology , Hypesthesia/physiopathology , Injections, Intramuscular , Middle Aged , Paresthesia/etiology , Paresthesia/physiopathology , Treatment Outcome , Vitamin B 12 Deficiency/complications , Vitamin B 12 Deficiency/drug therapy , Vitamin B 12 Deficiency/physiopathology , Vitamin B Complex/therapeutic useABSTRACT
The interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and autoimmune thyroid disease is an emerging phenomenon. The present study describes the case of a 28-year-old female who experienced a relapse of Graves' disease following SARS-CoV-2 infection. She was biochemically euthyroid for 2 years prior to COVID-19 infection. However, she began experiencing palpitations, increased sweating and tremors of the hands 9 days after being diagnosed with COVID-19-related pneumonia. In addition to presenting this case, a comparison is made of this case to similar reports and the possible mechanisms underlying the association between SARS-CoV-2 and Graves' disease are discussed. One is a direct result of viral uptake by thyroid cells, while another is a result of the hyperinflammatory 'cytokine storm' and its effects on the hypothalamic-pituitary-thyroid axis and T-cell immunity.
