1.
Med Hypotheses
; 81(6): 1041-5, 2013 Dec.
Article
in English
| MEDLINE
| ID: mdl-24182870
ABSTRACT
Intrinsic radio-sensitivity is the determinant of differential response of tumours to low LET ionising radiations. The probabilistic DNA fibril both model shows intrinsic radio-sensitivity factor [I] as function of nuclear diameter (Nd) and intra cellular hydrogen ion concentration [H+]. Linking probabilities of lethal and sub-lethal events to [I] further results in equations which show the LQ parameters namely alpha and beta are functions of (Nd), [H+] and repair constant (µ) mu. This model is able to explain radiobiological phenomena of OER and Do value of lymphocytes.