Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 5 de 5
Filter
Add more filters










Database
Language
Publication year range
1.
Biotechnol Prog ; 35(4): e2823, 2019 07.
Article in English | MEDLINE | ID: mdl-31017346

ABSTRACT

The rare earth metal oxide nanoparticles such as gadolinium oxide nanoparticles (Gd2 O3 NPs) have been synthesized by green synthesis process using methanolic extract of Moringa oleifera (M oleifera) peel. In this process, the Gd2 O3 NPs formation was observed at 280-300 nm in UV-Vis spectroscopy. The XRD pattern of the synthesized Gd2 O3 NPs was exactly matched with JCPDS No 3-065-3181which confirms the crystalline nature of Gd2 O3 NPs. In addition, Energy-dispersive X-ray spectroscopy (EDX) analysis was stated that Gd and O elements were present as 70.31 and 29.69%, respectively in Gd2 O3 NPs. The SEM and TEM analysis were said Gd2 O3 NPs are in rod shape and 26 ± 2 nm in size. Further the synthesized Gd2 O3 NPs were confirmed by X-ray photoemission spectroscopy (XPS). The synthesized Gd2 O3 NPs were further examined for anti-fungal activity against Alternaria saloni (A saloni) and Sclerrotium rolfsii (S rolfsii) and it showed moderate activity. Also, Gd2 O3 NPs evaluated as good antibacterial agent against different Gram +ve and Gram -ve bacteria. Moreover, the toxicity of the Gd2 O3 NPs on red blood cells (RBCs) of the human blood was determined using hemolytic assay, the obtained results were stated the synthesized Gd2 O3 NPs are nontoxic to the human erythrocytes. The photocatalytic activity against malachite green (MG) dye was tested and confirmed as 92% of dye was degraded within 2 hr by Gd2 O3 NPs. The results were stated the green synthesized Gd2 O3 NPs are good anti-fungal agents, nontoxic and we can use as a photocatalyst. Copyright © 2019 John Wiley & Sons, Ltd.


Subject(s)
Anti-Bacterial Agents/chemistry , Antifungal Agents/chemistry , Coloring Agents/chemistry , Gadolinium/chemistry , Models, Chemical , Nanoparticles/chemistry , Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Antifungal Agents/chemical synthesis , Antifungal Agents/pharmacology , Bacteria/drug effects , Catalysis , Coloring Agents/chemical synthesis , Coloring Agents/pharmacology , Erythrocytes , Fungi/drug effects , Gadolinium/pharmacology , Green Chemistry Technology , Humans , Microbial Sensitivity Tests , Microwaves , Moringa oleifera/chemistry , Photochemical Processes , Plant Extracts/chemistry , Spectrometry, X-Ray Emission , Spectrophotometry, Ultraviolet , Surface Properties
2.
Artif Cells Nanomed Biotechnol ; 45(8): 1581-1587, 2017 Dec.
Article in English | MEDLINE | ID: mdl-27908201

ABSTRACT

In recent decades, several scientists focused their process towards nanoparticles synthesis by using various sustainable approaches. Cocos nucifera (C. nucifera) was one of the versatile trees in tropical regions which also can act as a thrust quencher in all over the world. Cocos nucifera coir was one of the waste by-products in all coconut-refining industries and with the help C. nucifera coir, Palladium nanoparticles (Pd NPs) were synthesized. Green-synthesized spherical-shape Pd NPs were over layered by secondary metabolites from C. nucifera coir extract and with an average particle size of 62 ± 2 nm, which were confirmed by morphological analysis. Eco-friendly mediated Pd NPs were further subjected to several biological applications like larvicidal against Aedes aegypti (A. aegypti) and anti-feedent, ovicidal, and oviposition deterrent against agricultural pest Callasobruchus maculates (C. maculates) and compared with C. nuciferacoir methanolic extract, which results in LC50 value of 288.88 ppm and LC90 value of 483.06 ppm using LSD-Tukey's test against dengue vector (A. aegypti). Cocos nucifera coir methanolic extract shows significant output while compared with Pd NPs towards anti-feedent assays; ovicidal activity and oviposition deterrent were discussed here.


Subject(s)
Agriculture , Cocos/chemistry , Larva , Metal Nanoparticles/chemistry , Palladium/chemistry , Pest Control , Pesticides/chemical synthesis , Aedes/physiology , Animals , Chemistry Techniques, Synthetic , Green Chemistry Technology , Larva/physiology , Oviposition/drug effects , Pesticides/chemistry , Pesticides/pharmacology
3.
Molecules ; 21(11)2016 Nov 18.
Article in English | MEDLINE | ID: mdl-27869743

ABSTRACT

This study deals with a new and efficient metal-free regioselective synthesis of pyrimido-fused indazoles with nitrogen ring junction motifs. We have developed a metal-free domino type reaction between 3-aminoindazole, aryl aldehydes and aceotophenones in the presence of KOH/DMF that leads to pyrimido[1,2-b]indazole analogues. Response Surface Methodology (RSM) coupled with a Box-Behnken design (BBD) were utilized for exploring the effect of base used (A), temperature of reaction (B) and (C), reaction time. This approach can allow access to a variety of pyrimidoindazole fluorophores and related compounds. The compound N,N-dimethyl-4-(2-phenylpyrimido[1,2-b]indazol-4-yl)aniline (4e) displays the maximum fluorescence intensity at 518 nm and shows a fluorescence quantum yield of 0.068. The synthesized pyramido-fused indazoles have been evaluated for their free radical scavenging activity and compound 4f showed good antioxidant activity.


Subject(s)
Free Radical Scavengers/chemical synthesis , Indazoles/chemical synthesis , Pyrimidines/chemical synthesis , Free Radical Scavengers/chemistry , Free Radical Scavengers/pharmacology , Indazoles/chemistry , Indazoles/pharmacology , Molecular Structure , Nitrogen/chemistry , Oxidative Stress/drug effects , Pyrimidines/chemistry , Stereoisomerism
4.
Appl Microbiol Biotechnol ; 100(11): 4803-16, 2016 Jun.
Article in English | MEDLINE | ID: mdl-27100529

ABSTRACT

In past decades, the possibility of using high atomic number nanoparticle has gained interest in gel dosimetry to enhance the dose deposited in the tumor while using low radiation as well as for better imaging purposes. Sparing of healthy tissues and targeting the tumor part have become much more captivating with the help of these systems. The gel dosimetry is a the three-dimensional dosimeter for extracting the dose, which can be used along with the nanoparticles like gold, platinum, and silver, for better therapeutic efficiency for modern radiotherapy techniques. These nanoparticles of different size prepared either by chemical route or green synthesis and incorporated into the gel system respond in a different manner. Having wide applications in therapeutic field, this study reviews the use of gel dosimeters in the therapeutic procedures and also with the aid of nanoparticles so as to achieve dose enhancement. The biological activity of the various nanoparticles has been discussed.


Subject(s)
Gels/chemistry , Metal Nanoparticles/chemistry , Radiometry/instrumentation , Radiotherapy Dosage , Animals , Bismuth/chemistry , Bismuth/pharmacology , Cell Line, Tumor , Disease Models, Animal , Gadolinium/chemistry , Gels/pharmacology , Gold/chemistry , Gold/pharmacology , Hafnium/chemistry , Humans , Iodine/chemistry , Iron/chemistry , Iron/pharmacology , Nanotechnology , Neoplasms/drug therapy , Neoplasms/radiotherapy , Oxides/chemistry , Platinum/chemistry , Platinum/pharmacology , Silver/chemistry , Silver/pharmacology
5.
Pharm Biol ; 54(5): 759-69, 2016.
Article in English | MEDLINE | ID: mdl-26452728

ABSTRACT

CONTEXT: Citrus limon (L.) Burm.f. (Rutaceace) is a commonly available fruit variety with high medicinal and industrial values. OBJECTIVE: Lemon peel (LP) extract was studied as a potent preventive and curative agent for experimentally induced hyperoxaluric rats. MATERIALS AND METHODS: Gas chromatography-mass spectrometry (GC-MS) analyses and toxicity study were performed for aqueous methanol LP extract. Twenty-four Wistar rats were segregated into four groups. Group 1: Control; Group 2: Urolithic (ethylene glycol (EG) - 0.75%); Group 3: Preventive study (EG + LP extract administration from 0th to 7th week); Group 4: Curative study (EG + LP extract administration from 4th to 7th week). Animals received LP extract daily by oral administration (100 mg/kg body weight) for 7 weeks. RESULTS AND DISCUSSION: GC-MS analyses revealed that compound 6 was abundant in the LP extract (32%) followed by compound 1 (∼21%). The LD50 value of LP extract was found to be >5000 mg/kg of body weight. Urolithic rats showed significantly higher urinary calcium and oxalate (4.47 ± 0.44 and 18.86 ± 0.55 mg/24 h, respectively) excretion compared with control and experimental rats. Renal function parameters like urea (84 ± 8.5 and 96.1 ± 3.6 mg/dL), creatinine (1.92 ± 0.27 and 1.52 ± 0.22 mg/dL), and urinary protein (2.03 ± 0.02 and 2.13 ± 0.16 mg/24 h) were also reduced by LP extract (p < 0.001) and corroborated with tissue analyses (SOD, catalase, and MDA levels) and histological studies in normal and experimental animals. Immunohistochemical staining of THP and NF-κB in urolithic animals showed elevated expression than the control, while LP extract suppressed the expression of these proteins. CONCLUSION: In conclusion, lemon peel is effective in curing kidney stone disease and also can be used to prevent the disease and its recurrence.


Subject(s)
Citrus , Fruit , Methanol/therapeutic use , Plant Extracts/therapeutic use , Urolithiasis/prevention & control , Water , Animals , Ethylene Glycol/toxicity , Female , Plant Extracts/isolation & purification , Rats , Rats, Wistar , Treatment Outcome , Urolithiasis/chemically induced , Urolithiasis/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...