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Blut ; 34(4): 299-304, 1977 Apr.
Article in English | MEDLINE | ID: mdl-403985

ABSTRACT

A patient with "chronic cold-agglutinin disease" is described. Initially, the process was a benign monoclonal gammopathy. After an intervall of 6 years clinical, cytomorphological and immunochemical studies showed progress towards malignancy. In the bone marrow intranuclear lipid-like inclusions appeared in the plasma cells.


Subject(s)
Paraproteinemias/pathology , Agglutinins , Autoantibodies , Bone Marrow/ultrastructure , Cold Temperature , Humans , Hypergammaglobulinemia/pathology , Immunoglobulin M , Immunoglobulin kappa-Chains , Male , Microscopy, Electron , Plasma Cells
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