ABSTRACT
The relation between plasma lipids and gallbladder disease was examined by using data collected between 1984 and 1987 from 1,303 Rancho Bernardo, California, women aged 50 years and older. In univariate analyses and after adjustment for age and body mass index, high density lipoprotein cholesterol (HDL cholesterol) and low density lipoprotein cholesterol (LDL cholesterol) were inversely related and triglyceride level was positively related to gallbladder disease. However, using multiple logistic regression, only LDL cholesterol, triglycerides, age, and body mass index were significantly related to a history of gallbladder disease, whereas HDL cholesterol was no longer associated with gallbladder disease. The risk of gallbladder disease increased with greater age, body mass index, and triglyceride level, but decreased with increasing LDL cholesterol level. Total amount of alcohol consumed per week, number of cigarettes smoked per day, and current estrogen use were not significantly associated with gallbladder disease. The relation of HDL cholesterol and LDL cholesterol to the risk of gallbladder disease requires further investigation.
Subject(s)
Cholesterol/blood , Gallbladder Diseases/blood , Gallbladder Diseases/epidemiology , Triglycerides/blood , Age Factors , Aged , Aged, 80 and over , Alcohol Drinking , Analysis of Variance , Body Mass Index , California/epidemiology , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Estrogen Replacement Therapy , Female , Humans , Middle Aged , Regression Analysis , SmokingABSTRACT
The Air Force Aerospace Medical Research Laboratory was officially redesignated as the Harry G. Armstrong Aerospace Medical Research Laboratory (AAMRL) during a 2-day celebration on 5-6 June, 1985, honoring the Laboratory's founding director, Maj. Gen. Harry G. Armstrong. The mission and current programs of the Laboratory encompass basic and applied research and development in the fields of toxicology, biodynamics and human engineering. Looking to the next 50 years, the Harry G. Armstrong Aerospace Medical Research Laboratory will maintain its commitment to both creative and innovative research. The most compelling opportunities seen at this time include understanding biological pattern recognition phenomena at the cell, organ, and whole-organism levels; advanced measurement techniques to probe biological functions in real time; analytic modeling to capture mechanisms for action; and developments in machine intelligence to permit natural, two-way communication between man, computer, and system. The continuing challenge for the Laboratory remains, as always, the enhancement of military man and mission.
