ABSTRACT
UNLABELLED: Due to missing indications for specific diagnostics, the majority of non-symptomatic vertebral fractures are not diagnosed. This study shows the ability of radiation-free spinometry to assess sagittal spine parameters to raise suspicion for new non-traumatic thoracic and lumbar vertebral fractures and indicate specific diagnostics. INTRODUCTION: The primary aim of this study was to investigate the accuracy of radiation-free spinometry to predict new non-traumatic vertebral fractures (VF) by the assessment of thoracic kyphosis (TK), lumbar lordosis (LL), and trunk inclination. METHODS: Three hundred sixty-one patients (278 females and 83 males; age, 67.0 ± 8.6 years) were enrolled. In 86 women and 24 men, at least one non-traumatic VF was confirmed by radiography, MRI, and/or CT. Spinometry (video rasterstereography) was used to assess TK, LL, and trunk inclination. Receiver operating characteristic (ROC) and multivariate logistic regression analyses were performed to test the influence of age, sex, number, location, and grade of fractures on sagittal spine alignment. RESULTS: TK, LL, and trunk inclination were associated with advancing age (p < 0.05). Patients with prevalent thoracic and lumbar VFs showed increased TK (p < 0.001), decreased LL (p < 0.001), and increased trunk inclination (p < 0.001) in comparison to patients without VFs. ROC analysis revealed that the combination of TK and LL presented with the best predictive accuracy to raise suspicion for new grade 2 or grade 3 VFs in the thoracic and the lumbar spine (AUC, 0.752-0.771). Odds ratio (OR) showed an increased risk for VFs with increased TK (OR, 1.05-1.11; p < 0.001) and LL (1.05-1.07; p < 0.001) in specified regions of interest. A TK <50° (sensitivity, 88-100 %; specificity, 23-25 %) and LL (78-92 %; 24-27 %) were considered as appropriate cutoffs for future screening. CONCLUSION: Spinometry showed better predictive accuracy than historical height loss. Severe changes of TK and LL may help to raise suspicion of new VFs radiation-free and indicate proper diagnostics, such as radiographs, MRI, or CT.
Subject(s)
Lumbar Vertebrae/injuries , Osteoporotic Fractures/diagnosis , Spinal Fractures/diagnosis , Thoracic Vertebrae/injuries , Aged , Aged, 80 and over , Female , Humans , Imaging, Three-Dimensional/methods , Kyphosis/diagnosis , Kyphosis/etiology , Kyphosis/pathology , Lordosis/diagnosis , Lordosis/etiology , Lordosis/pathology , Lumbar Vertebrae/pathology , Male , Middle Aged , Osteoporotic Fractures/complications , Osteoporotic Fractures/pathology , Photogrammetry/methods , Sensitivity and Specificity , Sex Factors , Spinal Fractures/complications , Spinal Fractures/pathology , Thoracic Vertebrae/pathologyABSTRACT
UNLABELLED: PRELIMINARY REMARKS: The prevalence of central auditory processing disorders (CAPD) is supposed to be 2-3% of all children. Given the number of affected children and restricted resources in the public health there is a need for an effective and evaluated therapeutic approaches. On the other hand the number of outcome studies is remarkably small. PATIENTS AND METHODS: The presented study reports strategies and pitfalls in outcome measurements of 34 children with CAPD, based upon a 3-weeks indoor therapeutic intervention. Diagnostic criteria of auditory processing and perception were recorded before and after therapy. RESULTS: The data shows a highly significant improvement of certain perceptive abilities, including audiological parameters (dichotic testing, discrimination, loudness scaling) and awareness, psycholinguistic development and orthographic tests. CONCLUSION: The study demonstrates that an effective therapy of CAPD in children is possible and scientifically proven. Long term surveillance however seems to be necessary. It also has to be studied whether intensive indoor treatment is superior or equal to out clinic therapy.
