1.
Fiziol Zh (1994)
; 53(3): 3-8, 2007.
Article
in Ukrainian
| MEDLINE
| ID: mdl-17725037
ABSTRACT
Ecdysterone (100 ng/100 g) chronic oral administration (2 months after STZ (5 mg/100 g) administration) normalized plasma glucose levels in rats. This potent hypoglycemic effect of ecdysterone depend on inhibition of non-constitutive NO synthesis by Ca(2+)-independent iNOS and NADP-dependent nitrate reductase as well as inhibition of L-arginine degradation by arginase result in up-regulation of Ca(2+)-dependent constitutive NO synthesis by eNOS or mithochondrial nNOS in heart and aorta of rats.