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Bioorg Med Chem Lett
; 14(3): 797-800, 2004 Feb 09.
Article
in English
| MEDLINE
| ID: mdl-14741292
ABSTRACT
Further SAR studies on the thiophene-2-carboxylic acids are reported. These studies led to the identification of a series of tertiary amides that show inhibition of both HCV NS5B polymerase in vitro and HCV subgenomic RNA replication in Huh-7 cells. Structural insights about the bioactive conformation of this class of molecules were deduced from a combination of modeling and transferred NOE (trNOE) studies.