Machine Learning Model for Predicting CVD Risk on NHANES Data.

Cardiovascular disease (CVD) is a major health problem throughout the world. It is the leading cause of morbidity and mortality and also causes considerable economic burden to society. The early symptoms related to previous observations and abnormal events, which can be subjectively acquired by self-assessment of individuals, bear significant clinical relevance and are regularly preserved in the patient's health record. The aim of our study is to develop a machine learning model based on selected CVD-related information encompassed in NHANES data in order to assess CVD risk. This model can be used as a screening tool, as well as a retrospective reference in association with current clinical data in order to improve CVD assessment. In this form it is planned to be used for mass screening and evaluation of young adults entering their army service. The experimental results are promising in that the proposed model can effectively complement and support the CVD prediction for the timely alertness and control of cardiovascular problems aiming to prevent the occurrence of serious cardiac events.

Extracting reliable gene expression signatures through Stable Bootstrap Validation.

Identification of candidate genes responsible for specific phenotypes, such as cancer, has been a major challenge in the field of bioinformatics. Given a DNA Microarray dataset, traditional feature selection methods produce lists of candidate genes which vary significantly under variations of the training data. That instability hinders the validity of research findings and raises doubts about the reliability of such methods. In this study, we propose a framework for the extraction of stable genomic signatures. The proposed methodology enforces stability at the validation step, independent of the feature selection and classification methods used. The statistical significance of the selected gene set is also assessed. The results of this study demonstrate the importance of stability issues in genomic signatures, beyond their prediction capabilities.