[THE INFLUENCE OF CYTOFLAVIN AND CARDIOXIPIN ON THE PARAMETERS OF 24-HOUR ARTERIAL PRESSURE MONITORING IN PATIENTS WITH CHRONIC CEREBRAL CIRCULATION INSUFFICIENCY, ARTERIAL HYPERTENSION AND HYPERCHOLESTEROLEMIA].

This comparative study of the influence of cytoflavin and cardioxipin on the parameters of 24-hour arterial pressure monitoring in 56 patients with chronic cerebral circulation insufficiency, arterial hypertension and hypercholesterolemia included 32 women and 24 men aged 42-72 years divided into 3 groups matchedfor the stage of diseases, age, sex, severity of AH, total cholesterol level, and antihypertensive therapy. Patients of group 1 were treated without cytoflavin and cardioxipin. Those in group 2 received daily i/v droplet infusion of 10 mg/kg cardioxipin (20-30 droplets/min). Patients of group 3 were given daily i/v droplet infusion of 10 ml cytoflavin in 200 ml 0.9% sodium chloride solution for 10 days. 24-hour arterial pressure monitoring was used to estimate the influence of the two drugs on systolic and diastolic pressure, its daily rhythm, AP variability and frequency of elevation. The study showed that both therapeutic modalities improved daily AP rhythm as manifested in a significant increase of the number of patients with the dipper rhythm and a decrease in the number of systolic/diastolic non-dipper patients. Moreover cytoflavin significantly decreased the number of systolic over-dippers compared with control group.

[The assessment of the effects of cytoflavin and cardioxipin on the emotional status of rats with dyslipidemia].

OBJECTIVE: To compare the effects of cytoflavin and cardioxipin on the emotional status of rats with experimental disturbance of lipid metabolism using the uplifted cruciform labyrinth method. MATERIAL AND METHODS: The disturbance of lipid metabolism was induced by the introduction of exogenic cholesterol-in -oil emulsion in dosage 40 mg /kg of body mass during 20 days. Pharmacological treatment was performed in the 11th day. The drugs were injected intraperitoneally during 10 days: cytoflavin in dose 1,75 ml/ kg (175 mg/kg with succinic acid), cardioxipin in dose 52,5 mg/kg. RESULTS AND CONCLUSION: Cytoflavin and cardioxipin caused the positive changes in the parameters of emotional status of rats in conditions of experimental dyslipidemia.

[The influence of cytoflavin and cardioxipin on the indices of lipid peroxidation and antioxidant protection in the blood of rat with dyslipidemia].

Comparative tests on nonlinear rats of both sex with model violation of lipid metabolism have been performed in order to study the effects of cytoflavin (1.75 ml/kg or 175 mg/kg with respect to succinic acid) and cardioxipin (52.5 mg/kg) on lipid peroxidation and antioxidant protection indices in the blood. It is established that these preparations cause a decrease in the content of malonic dialdehyde (MDA) in erythrocytes that results in increased antioxidant activity and lipid reserves for peroxidation in the blood.

[A comparative study of the myeloprotective effect of dicarbamine and leucostim in experimental post-radiation bone marrow syndrome].

We studied the effect of dicarbamine and leucostim on myelopoiesis in experimental post-radiation bone marrow syndrome. Dicarbamine in different modes of administration and doses provided a high level of protection of proliferating hematopoietic precursors in the early period after radiation, which was reflected in a statistically significant decrease in the depth and duration of post-radiation deficit of cells, such as of granulocytes, lymphocytes, megakaryocytes and erythroid cells. The greatest effect of the drug appeared at a dose of 4 mg/kg (prophylactic administration) and a dose of 15 mg/kg (curative double dose). In the bone marrow of experimental animals leucostim prevented development of post-radiation deficit of granulocytes and lymphocytes to a lesser extent, than dicarbamine, and it was effective for erythroid cells and megakaryocytes.

[Modification of hematosupressive action of ionizing radiation by dicarbamine].

There was studied the effect of different doses of Dicarbamine by means of oral medical-prophylactic and medical administration on the peripheral blood of rabbits in conditions of experimental radiation damage to the blood system. The drug provided the safety of circulating red blood cells at rather high level, prevented the development of severe post-radiation thrombocytopenia, reduced post-radiation leukocytopenia, accelerated processes of recovery of peripheral blood leukocytes to the initial level by segmented neutrophils and lymphocytes.

[Comparative study of the hemato-protective effect of Dicarbamine and Leykostime in experimental radiation damage to the blood system].

There was studied the influence Dicarbamine and Leykostime on peripheral blood leukocyte composition of rabbits in experimental radiogenic damage to the blood system. Dicarbamine significantly insured the safety of circulating red blood cells, prevented the development of severe postradiation thrombocytopenia, reduced postradiation leukocytopenia, and accelerated the recovery of peripheral blood leukocytes to the initial level by segmented neutrophils and lymphocytes. Leukostime ensured the safety of peripheral blood leukocytes however was less effective than Dicarbamine to prevent postradiation deficit of circulating red blood cells and thrombocytes.

[Hematoprotective effectiveness of dicarbamin in experimental post-radiation bone marrow syndrome].

The effect of dicarbamin on cellular composition of rabbits' venous blood in experimental post-radiation bone marrow syndrome was studied. The dicarbamin use has allowed to reduce depth and to shorten the duration of post-radiation leukocytopenia.

[Effect of dicarbamine on medullary hemopoiesis in experimental post-irradiation bone-marrow syndrome].

The effect of dicarbamine on hemopoiesis in experimental post-irradiation bone-marrow syndrome was studied. The myeloprotective activity of the drug was established. It manifested in the protection of hematopoietic progenitor cells and stimulation of cell proliferation and differentiation in the bone marrow.

[Comparison of stress protector activity of drugs with antioxidant activity (vitamin E, dimephosphon, reamberin) in rats].

The condition of the mucous membrane and lipid spectrum of tissue structures under the action of gastric ulcerogenic stress factors was studied on the background of administration of vitamin E, dimephosphon, and reamberin. The use of antioxidants, especially reamberin, led to the restoration of lipid metabolism and normalization of lipid peroxidation processes.

[Antiulcerous efficacy of reamberin at the background of the stress ulcerogenic factor action].

The effect of reamberin on morphofunctional changes in the small intestine mucous membrane due to stress ulcerogenesis was studied. Normalization of the lipid modifications in the tissue structure, evident of the drug antiulcerous properties, was observed.

[Effect of dicarbamin on postradiation leukocyte composition dynamics in peripheral blood of mice].

Effects of dicarbamin on the post-irradiation dynamics of leukocyte composition in the peripheral blood of mice have been studied upon oral administration of the drug in a single dose of 0.5, 5.0, 15.0, and 50.0 mg/kg. It is established that the drug doses of 5.0, 15.0, and 50.0 mg/kg produce statistically significant radioprotective effects. The leukocyte fall decreases due to segmented neutrophils and lymphocytes. In addition, the drug accelerates the process of restoration of the leukocyte cell numbers on the initial level.

[Study of antiarrhythmic activity and duration of action of quaternidine]. / Issledovanie protivoaritmicheskoi activnosti i prodolzhitel'nosti deistviia kvaternidina.

The results of experiments on dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, produces a significant antiarrhythmogenic effect in cases of rhythm disorders in the late stage of a model myocardial infarction. For drugs administered in a single isotoxic dose, the therapeutic effect of quaternidine in animals with acute myocardial ischemia considerably exceeds the duration of action of lidocaine and trimecaine.

[The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia]. / Protivoaritmicheskaia aktivnost' ammonievogo proizvodnogo trimekaina na fone ishemicheskogo povrezhdeniia serdtsa.

The results of experiments on cats and dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, exceeds the structural precursors (trimecaine and lidocaine), as well as the reference drugs quinidine and propranolol, in intensity of the antiarrhythmic action upon single administration on the occlusive and reperfusive arrhythmia models. The therapeutic effect of quaternidine in animals with acute myocardial ischemia lasts for about 8 h, which more than 20 times longer as compared to the duration of action of both lidocaine and trimecaine.