Tetrahedral Keggin Core Tunes the Visible Light-Assisted Catalase-Like Activity of Icosahedral Keplerate Shell.

In this work, the effect of Keggin polyoxometalates encapsulated in Keplerate {Mo72Fe30} shell (K shell) on the visible light-assisted catalase-like activity (H2O2 dismutation) of the resulting core-shell clusters PMo12@K, SiMo12@K, and BW12@K was investigated. Superior photodismutation activity of PMo12@K compared to that of K shell and two other core-shell clusters was discovered. The homogeneity of PMo12@K and its improved oxidative stability, increased redox potential, and reduced band gap caused by a synergistic effect between the Keplerate shell and Keggin core seem reasonable to explain such a superiority. The light-dependent photocatalytic performance of PMo12@K evaluated by action spectra revealed a maximum apparent quantum efficiency (AQY) at 400 nm, demonstrating the visible light-driven photocatalytic reaction. A first-order rate constant of 2 × 10-4 s-1 and activation energy of 108.8 kJ mol-1 alongside a turnover frequency of 0.036 s-1 and a total turnover number of up to ∼3800 approved the effective photocatalytic activity and improved the oxidative stability of PMo12@K. A nonradical photocatalytic mechanism through a Fe-OOH intermediate was proposed. Thus, the structure, optical activity, and oxidative stability of a host Keplerate-type nanocluster can be tuned significantly by encapsulation of a guest, like "cluster-in-cluster" structures, which opens the scope for introducing new visible light-sensitive hierarchical nanostructures.

Licofelone Attenuates LPS-induced Depressive-like Behavior in Mice: A Possible Role for Nitric Oxide.

PURPOSE: Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, possesses antioxidant, antiapoptotic, neuroprotective, and anti-inflammatory properties. The aim of the present study was to investigate the effect of licofelone on lipopolysaccharide (LPS)-induced depression in a mouse model and also a possible role for nitric oxide (NO). METHODS: To elucidate the role of NO on this effect of licofelone (5 and 20 mg/kg, i.p.), L-NAME, a non-specific NO synthase (NOS) inhibitor; aminoguanidine (AG), a specific inducible NOS (iNOS) inhibitor; 7-nitroindazole (7-NI) a preferential neuronal NOS inhibitor (nNOS) and; L-arginine (L-Arg), as a NO donor, were used. The animal's behaviors were evaluated employing forced swimming test (FST), tail suspension test (TST) and open field test (OFT). RESULTS: LPS (0.83 mg/kg, i.p.) induced depressive-like behavior increasing immobility time in FST and TST. Conversely, licofelone (20 mg/kg i.p.) reversed the depressive effect of LPS and lowered the immobility time in FST and TST. On the other hand, pretreatment with L-Arg also reversed the antidepressant-like effect of licofelone (20 mg/kg) in FST and TST. On the other hand, L-NAME (10 and 30 mg/kg), AG (50 and 100 mg/kg) and 7-NI (60 mg/kg) could potentiate licofelone (5 mg/kg) and lowered the immobility duration. CONCLUSIONS: NO down-regulation possibly through iNOS and nNOS inhibition may involve in the antidepressant property of licofelone. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.