[Investigations into certain mechanisms of antinociceptive action of millimeter wavelengths].

Changes in skin susceptibility and afferent pulsation frequency were measured in n. saphenous of rats undergoing the action of ultrahigh frequency electromagnetic radiation (UHF EMR). The study was aimed at verifying the hypothesis of the involvement of interleukine-6 (L-6) and endocannabinoids in the realization of the antinociceptive effect of UHF EMR. It was shown that UHF EMR with a wavelength of 7.1 mm lowers tactile, temperature, and pain sensitivity of the skin. This change was shown to correlate with the decreased electrical activity of afferent conductors of n. saphenous. Moreover, the IL-6 level in rat blood sera increased within 10 minutes after the irradiation both in the case of LPS-induced polyphasic fever in intact animals and under the normal conditions. This finding can possibly point out to the participation of this cytokine in the mechanisms of the antinociceptive effect especially in the case of pain of inflammatory origin. The data obtained give evidence that UHF EMR and anandamide exert a synergistic effect which confirms the involvement of the endocannabinoid system in the mechanisms of the antinociceptive action of the physical factor under consideration.

[The influence of ultrahigh-frequency electromagnetic radiation and low-intensity laser radiation on the body core temperature and basal metabolism in rats with systemic inflammation].

The effects of ultrahigh-frequency electromagnetic radiation (UHF EMR) and low-intensity laser irradiation (LILI) on the body and skin temperature, oxygen consumption, production of carbon dioxide and heat release were investigated in the experiments on intact rats and during LPS-induced polyphasic fever. It was found that UHF EMR with the wavelength of 4,9 mm, 5,6 mm or 7,1 mm and LILI with the wavelength of 0.47 microm, 0.67 microm and 0.87 microm caused modulation of basal metabolism and thermal response to systemically administered lipopolysaccharide (LPS). These findings suggest that the most pronounced antipyretic and hypometabolic effects were observed after the treatment with UHF EMR at 7,1 mm and LILI at 470 microm.