Melanoma mucoso de senos paranasales / Mucosal melanoma of the paranasal sinuses

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Profundidad tumoral en el carcinoma epidermoide lingual. Repercusiones diagnósticas / Tumor depth in squamous cell carcinoma of the tongue. Diagnostic repercussions

Objetivo. Determinar el grado de concordancia entre la valoraciónclínica (cT) e histopatológica (pT) del tamaño del carcinoma epidermoidelingual en relación a la introducción del parámetro de profundidadtumoral (ppT). Material y métodos. 1) Diseño: Estudio retrospectivo debase hospitalaria constituido por 60 pacientes evaluados desde Enero de1990 a Julio de 1997 (Seguimiento mínimo de 8 años). 2) Variables: Filiacióndel paciente, parámetros clínicos y parámetros histopatológicos. 3)Método estadístico: Correlación mediante el Indice Kappa (p< 0,005). Resultados.Tras la aplicación del parámetro “profundidad tumoral” se aprecia:• Correlación entre cT y ppT: Disminución del grado de concordanciaentre cT y pT en relación con ppT (23,3 y 12,5%).• Correlación entre pT y ppT: Concordancia del 100% entre pT4 y ppT4.Todos los tumores pT3 pasaron al estadío ppT4.Conclusión. Cuando se aplica el parámetro de profundidad tumoral se apreciaun desplazamiento del diagnóstico clínico e histopatológico hacia estadíosmás avanzados(AU)

Objective. To determine the degree of concordance betweenclinical (cT) and histopathological (pT) values for tumor sizein squamous cell carcinoma when introducing “tumor thickness”as a diagnostic marker. Materials and methods. 1) Design: A retrospectivehospital study of 60 patients evaluated between January1990 and July 1997 was carried out. 2) Variables: Patient dates,clinical and histopathological parameters. 3) Statistics: Correlationassessment by Kappa Index (p<0.05). Results. After the use of“tumor thickness” as a diagnostic indicator the following can beappreciated:• Correlation between cT and ppT: Reduction in the degree ofconcordance between cT and pT in relation to ppT (23.3 /12.5%).• Correlation between pT and ppT: 100% concordance betweenpT4 and ppT4. All tumors diagnosed as pT3 were changedto ppT4.Conclusion. When the parameter “tumor thickness” is used, a changecan be appreciated in the early stage clinical and histopathologicaldiagnosis, as tumor size (T) becomes advanced(AU)

Enfermedad ósea de Paget asintomática en adulto joven / Asymptomatic Paget´s bone disease in the young adult

Presentamos el caso clínico de un varón de 39 años, diagnosticado de enfermedad ósea de Paget, con afectación ósea craneal y aumento de fosfatasa alcalina sérica e isoenzima ósea. Se realiza revisión de las escasas publicaciones de la enfermedad de Paget en el adulto joven y se sugiere la necesidad de seguir clínicamente cohortes de pacientes con edad de inicio inferior a 40 años(AU)

We discussed the case of a 39 years old man, diagnosed with Paget´s bone disease, with cranial bone affection and raised levels in serum alkaline phosphatase and their bone isoenzyme. We present a review of a few published cases about Paget´s bone disease in early adult life and we suggest to need follow-up cohorts of Paget´s bone disease with early adult onset lower than 40 years(AU)

Arteritis de células gigantes y oclusión de la arteria central de la retina / Giant cell arteritis and retinal central artery oclussion

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Profundidad tumoral y variables histopatológicas en el carcinoma epidermoide lingual. Estudio retrospectivo sobre 60 pacientes / Tumoral thickness and histopathological parameters in the squamous cell carcinoma of tongue

I.- Introducción: La profundidad tumoral representa uno de los principales factores pronósticos del carcinoma epidermoide lingual. II.-Objetivos: Verificar si el espesor máximo tumoral se correlaciona con parámetros histopatológicos agresivos.III.-Material y Métodos: -Diseño: Estudio retrospectivo de base hospitalaria (Enero-1990 a Julio-1997) constituido por 60 pacientes afectos de carcinoma escamoso lingual.-Variables: Filiación del paciente, parámetros histopatológicos y profundidad tumoral.-Procedimientos de laboratorio.-Métodos estadísticos: Estadística descriptiva e inferencial (Método Bonferroni, C- Dunnet, Chi-cuadrado y test de Anova).IV.-Resultados: Asociación estadísticamente significativa entre Índice mitótico y profundidad tumoral(14,84;p<0,001).V.-Conclusiones: Profundidad tumoral e Índice mitótico se correlacionan y representan factores de mal pronóstico en el carcinoma epidermoide lingual (AU)

I.-Introduction: The tumoral thickness represents one of the most ominous prognostic factors of the squamouscell carcinoma of tongue. II.-Objectives: To verify if the tumoral thickness is relationated with others aggressive histopathologic parameters.III.-Material and Methods: -Design: A hospital population retrospective study (January-1990 to July-1997) of 60patients affected of carcinoma of tongue.-Variables: Data patients, histopathological parameters and tumoral thickness.-Laboratory procedures. -Stadistic methods: Descriptive and Inferential stadistical: Bonferroni method, C-Dunnet, Chi-square, Anova test…IV.-Results: There is a statistic association between mitotic Index and tumoral thickness (14,84; p<0,001).V.-Conclusions: Depth of invasion and mitotic Index are actually associated prognostic factors in the carcinoma epidermoid of tongue (AU)

Schwannoma parafaríngeo gigante: Diagnóstico diferencial y enfoque terapéutico / Giant parapharyngeal schwannoma: Differential diagnosis and therapeutic approach

Los procesos expansivos de localización parafaríngea representan entre el 0,5 y el 0,8% de todas las lesiones tumorales de cabeza y cuello. En su diagnóstico diferencial una de las principales entidades quehay que tener en cuenta, por su elevada frecuencia, son las lesiones neurogénicas (25-45% de incidencia en cabeza y cuello) cuya evolución, lenta en el tiempo, y su crecimiento expansivo, condicionan, en la mayoría delas ocasiones, una mínima repercusión clínica. Una correcta anamnesis acompañada de pruebas de imagen (TC, RM, arteriografía) orienta el diagnóstico de este tipo de lesiones de origen neurógeno. La opción terapéutica más consensuada es la exéresis quirúrgica, siendo necesaria en determinadas ocasiones la embolización tumoral en las 24-48 horas previas a la intervención. Presentamos un caso de schwannoma parafaríngeo gigante, prácticamente asintomático y de aproximadamente cinco años de evolución, haciendo especial hincapié en su manejo diagnóstico y terapéutico, así como una revisión actualizada de los posibles diagnósticos diferenciales de masas parafaríngeas y de los protocolos de actuación frente a este tipo de lesiones

Expansive processes of parapharyngeal locationrepresent between 0.5% and 0.8% of all tumorous lesionsin the head and neck. In their differential diagnosis, one of the main considerations that must be kept in mind due to their high frequency are neurogenic lesions (25-45% incidence in the head and neck) with an evolution that is slow and expansive growth, clinical repercussions are minimal in the majority of cases. A correct anamnesis, accompanied by imaging tests (CT, MR, arteriography), is informative for the diagnosis of this type of lesion with a neurogenic origin. Themost agreed upon therapeutic option is surgical removal with embolization of the tumor 24-48 hours before the operation being necessary in certain situations.We present a case of giant parapharyngeal schwannoma,that was practically asymptomatic, and had been developing for approximately 5 years, putting special emphasis on diagnostic and therapeutic management, as well as an updated review of the possible differential diagnoses of parapharyngeal masses and the protocols for working with this type of lesion

Cloning of the gene encoding the p30 antigen of Toxoplasma gondii by PCR to insert it in transgenic mice.

The serum from virtually all people exposed to Toxoplasma gondii contains a high titer of antibodies against a major antigen called P30. It has been suggested that p30 antigen can be used as a good diagnostic tool during T. gondii infection. Polymerase chain reaction (PCR) is the most widely used method for amplifying a known of nucleic acid fragment. We have cloned the P30 gene by PCR using oligonucleotide primers, based on the reported sequence of the T. gondii p30 gene, and introduced it into the pEV142 expression vector. Work is in progress to explore the use of pEV142 expression vector in transgenic mice in order to study the immunological role of p30 antigen during T. gondii infection.

[Capture immunoassay for the detection of human IgG against Toxoplasma gondii protein P30]. / Inmunoensayo de "captura" para la detección de IgG humana anti proteína P30 de Toxoplasma gondii.

Toxoplasmosis is a widely distributed disease with prevalence rates ranging between 40 and 80% in different parts of the world. The diagnosis of congenital toxoplasmosis constitutes a health problem since intra-uterine infection can lead to undesirable effects on the fetus. Immunoenzymatic methods are the techniques of choice for the serologic diagnosis of toxoplasmosis. The present paper describes an indirect sandwich ELISA with the murine anti-P30, the main surface antigen of Toxoplasma gondii, monoclonal antibody as the first antibody fixed to the polystyrene 96 wells plate for the capture of P30 molecule from T. gondii extracts and to detect the presence of human anti-P30 IgG. Serum samples from 42 pregnant women were studied and compared to results obtained with a commercial kit (Plastelia Toxo IgG, Institute Pasteur, Lille, France) for the same purpose, in which 83.4% of the serum samples were positives. Our results demonstrated a significant correlation (p < 0.001; r = 0.84) with those obtained with the commercial kit. We conclude that the IgG anti-P30 method should be very useful for screening of seroconversion in pregnant women not sensitized by T. gondii and to evaluate epidemiologically the prevalence rate infection by this parasite which can cause and transmit this disease subclinically.