Marked underestimation of blood pressure control with conventional vs. ambulatory measurements in an urban, developing community of African ancestry.

BACKGROUND: As groups of African descent may have higher nocturnal blood pressure (BP) for a given day BP than other ethnic groups, we ascertained whether this translates into differences in conventional (CBP) and 24-h ambulatory (ABP) BP control at a community level. METHODS: Ambulatory 24-h, day and night BP (model 90207; SpaceLabs, Issaquah, WA) and CBP (mean of five values) control rates were determined in 689 randomly selected participants (>16 years) of African ancestry in South Africa. Target organ effects were determined from urinary microalbumin-to-creatinine ratios (ACR) and aortic pulse wave velocity (PWV, applanation tonometry). RESULTS: Of the participants 45.7% were hypertensive and 22.6% were receiving antihypertensive medication. More participants had uncontrolled BP at night (34.0%) than during the day (22.6%, P < 0.0001). Uncontrolled CBP was noted in 37.2% of participants, while a much lower proportion had uncontrolled ABP (24.1%) (P < 0.0001). Marked differences in the proportion of hypertensive participants with uncontrolled CBP and ABP were noted (treated: CBP = 62.2%, ABP = 33.3%, P < 0.0001; all: CBP = 81.3%, ABP = 44.4%, P < 0.0001). These differences were accounted for by a high prevalence of isolated increases in CBP (white-coat effects) (treated = 35.9%; all = 39.4%). Indeed, after censoring data from participants with white-coat effects, similar CBP and ABP control rates were noted. Participants with white-coat effects had similar ACR and PWV values as participants with normal ABP and CBP. CONCLUSIONS: In communities of African descent, despite worse BP control at night than during the day, a high prevalence of white-coat effects translates into a striking underestimation of BP control in hypertensives when employing CBP rather than ABP measurements.

Nurse-recorded auscultatory blood pressure at a single visit predicts target organ changes as well as ambulatory blood pressure.

AIM: To determine whether high-quality nurse-recorded auscultatory blood pressure (BP) values obtained at a single visit predict cardiovascular target organ changes as closely as ambulatory BP measurements. METHODS: In a randomly selected population sample (n = 458, 21% receiving antihypertensive treatment; approximately 40% hypertensive), we compared high-quality single visit nurse-recorded auscultatory BP values to same-day 24-h ambulatory BP in their ability to predict multiple target organ changes [left ventricular mass index (LVMI), left ventricle (LV) mean wall thickness (MWT), early-to-late transmitral velocity ratios (E/A), (echocardiography); log of urinary albumin-to-creatinine ratios (log ACR) (24-h urine samples); large artery dysfunction [carotid-femoral pulse wave velocity (PWV) and central augmentation index (Alc) (applanation tonometry)]. RESULTS: Nurse-recorded systolic BP (SBP) measurements obtained at a single visit were as closely associated with LVMI (r = 0.44), LV MWT (r = 0.44), E/A (r = -0.55), log ACR (r = 0.20), PWV (r = 0.62) and AIc (r = 0.41) (P < 0.0001 for all relations) as was 24-h SBP (LVMI; r = 0.33, LV MWT; r = 0.37, E/A; r = -0.35, log ACR; r = 0.24, PWV; r = 0.41, and AIc; r = 0.18, P < 0.001 for all relations) and either day or night SBP. On multivariate regression analysis with both nurse-recorded SBP and 24-h SBP in the same model, nurse-recorded SBP was independently associated with LVMI (P = 0.006), LV MWT (P = 0.03), E/A (P < 0.02), PWV (P < 0.0001) and AIc (P = 0.0002), and 24-h SBP was independently and positively associated with log ACR (P < 0.005), and PWV (P = 0.01). CONCLUSION: One or more, high-quality single visit nurse-recorded auscultatory BP measurements may be equally as effective as ambulatory BP in predicting target organ damage in a population sample of African ancestry.