1.
Arzneimittelforschung
; 27(2): 343-52, 1977 Feb.
Article
in English
| MEDLINE
| ID: mdl-577150
ABSTRACT
A series of 7-substituted alkyl-thio-acylaminocephalosporins with the following general formula were prepared and tested for in vitro antibacterial activity: (formula: see text). We tried in our research to find any relationship between antibacterial activity and pharmacokinetic properties on the one hand, and chemical structure on the other. The most interesting products were also studied for their in vivo antibacterial activity in experimental acute systemic infections in the mouse.
Subject(s)
Cephalosporins/chemical synthesis , Animals , Bacteria/drug effects , Blood Proteins/metabolism , Cephalosporins/blood , Cephalosporins/pharmacology , Chemical Phenomena , Chemistry , Half-Life , Kinetics , Mice , Microbial Sensitivity Tests , Protein Binding , Serum Albumin/metabolism , Structure-Activity Relationship
2.
Arzneimittelforschung
; 25(10): 1665, 1975 Oct.
Article
in English
| MEDLINE
| ID: mdl-1243055
3.
Arzneimittelforschung
; 23(8): 1090-100, 1973 Aug.
Article
in English
| MEDLINE
| ID: mdl-4801034
