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Clin Microbiol Infect ; 21(12): 1095.e5-9, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26344335

ABSTRACT

To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection.


Subject(s)
Staphylococcus aureus/genetics , Tetrahydrofolate Dehydrogenase/genetics , Trimethoprim Resistance , Bacterial Proteins/genetics , Europe , Humans , Soft Tissue Infections/microbiology , Staphylococcal Infections/microbiology , Staphylococcal Skin Infections/microbiology , Staphylococcus aureus/classification , Staphylococcus aureus/isolation & purification , Travel
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