ABSTRACT
PURPOSE: To describe the clinical findings in a patient with Parinaud's oculoglandular syndrome as an uncommon manifestation of primary herpes simplex virus type 1 (HSV-1) infection. METHODS: The clinical course, the laboratory findings, the therapy, and the outcome regarding a 14-year-old girl are described. RESULTS: The culture and PCR detection of HSV-1 on conjunctiva and skin scrapings, along with seroconversion to HSV, confirmed the etiology. The oral and local acyclovir therapy led to a prompt improvement in the patient's symptoms. CONCLUSION: The solitary ocular-glandular syndrome due to HSV-1 primary infection has never been reported before. Parinaud's oculoglandular syndrome is found in 5% of patients with cat-scratch disease and only on rare occasion associated with other conditions. Herpetic infection should be considered in the differential diagnosis of young patients with conjunctivitis, periorbital swelling, and painful preauricular and submandibular lymphadenopathy, combined with systemic symptoms of malaise and fever.
Subject(s)
Eye Infections, Viral/complications , Herpes Simplex/complications , Herpesvirus 1, Human/isolation & purification , Ocular Motility Disorders/etiology , Acyclovir/therapeutic use , Adolescent , Antibodies, Viral/analysis , Antiviral Agents/therapeutic use , DNA, Viral/analysis , Diagnosis, Differential , Eye Infections, Viral/drug therapy , Eye Infections, Viral/virology , Female , Follow-Up Studies , Herpes Simplex/drug therapy , Herpes Simplex/virology , Herpesvirus 1, Human/genetics , Herpesvirus 1, Human/immunology , Humans , Ocular Motility Disorders/diagnosis , Ocular Motility Disorders/drug therapy , Polymerase Chain ReactionABSTRACT
OBJECTIVE: To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer. STUDY DESIGN: A cross-sectional survey on p53 allelotypes distribution in women with different grade of cervical lesions and with or without HPV infection, in comparison to the distribution on a control group of women cytologically normal and HPV negative. RESULTS: No statistically significant difference in the p53 polymorphism distribution was found in relation to the infection with HPV, the cytological pattern and both conditions. A modest but constant over-representation of Pro-allelotypes was found in all groups in comparison to the control group. CONCLUSION: Searching for p53 polymorphism in a clinical setting does not seem to support secondary prevention procedures, at least for women in this area.
