Study of the Properties of CdS:Al (R = [Al3+]/[Cd2+] = 0.30, 0.40, 0.50) Thin Films Grown by the CBD Method in an Ammonia-Free System.

CdS:Al thin films were fabricated on a glass substrate using the CBD method. The effect of aluminum incorporation on the structural, morphological, vibrational, and optical properties of CdS thin layers was investigated by X-ray diffraction (XRD), Raman spectroscopy (RS), atomic force microscopy (AFM), scanning electron microscopy (SEM), and UV-visible (UV-vis) and photoluminescence (PL) spectroscopies. XRD analysis of deposited thin films confirmed a hexagonal structure with a preferred (002) orientation in all samples. The crystallite size and surface morphology of the films are modified with aluminum content. Raman spectra exhibit fundamental longitudinal optical (LO) vibrational modes and their overtones. Optical properties were studied for each thin film. Here, it was observed that the optical properties of thin films are affected by the incorporation of aluminum into the CdS structure.

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.

Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the C-terminal portion of LRRK2 (ΔLRRK2) with the G2019S mutation (ΔLRRK2G2019S) was sufficient to induce neurodegeneration of DA neurons in vivo, suggesting that mutated LRRK2 induces neurotoxicity through mechanisms that are (i) independent of the N-terminal domains and (ii) "cell-autonomous". Here, we explored whether ΔLRRK2G2019S could modify α-syn toxicity through these two mechanisms. We used a co-transduction approach in rats with AAV vectors encoding ΔLRRK2G2019S or its "dead" kinase form, ΔLRRK2DK, and human α-syn with the A53T mutation (AAV-α-synA53T). Behavioral and histological evaluations were performed at 6- and 15-weeks post-injection. Results showed that neither form of ΔLRRK2 alone induced the degeneration of neurons at these post-injection time points. By contrast, injection of AAV-α-synA53T alone resulted in motor signs and degeneration of DA neurons. Co-injection of AAV-α-synA53T with AAV-ΔLRRK2G2019S induced DA neuron degeneration that was significantly higher than that induced by AAV-α-synA53T alone or with AAV-ΔLRRK2DK. Thus, mutated α-syn neurotoxicity can be enhanced by the C-terminal domain of LRRK2G2019 alone, through cell-autonomous mechanisms.

Una mirada interseccional a las prácticas de salud en Aysén. Procesos de racialización en Chile / An intersectional view of health practices in Aysén. Racialization processes in Chile

Chile ha diversificado su población migrante a partir de la llegada de personas de América Lati-na y, a pesar de no ser estadísticamente significativo, esto ha generado una proliferación de imaginarios sociales negativos, afianzados institucionalmente a través de enfoques restrictivos hacia colectivos extranjeros. El racismo institucional se plasma en políticas, discursos y prácti-cas, ubicando en posiciones de desigualdades a algunos grupos migrantes. A través de una in-vestigación cualitativa llevada a cabo en la XI región de Aysén (Chile), y por medio de un análi-sisinterseccional, presentamos las maneras en que se articulan desigualdades como la proce-dencia nacional, la clase y el género, en la atención en salud pública. Los resultados muestran la existencia de prácticas racistas institucionales e imaginarios de “otredad” que les subyacen; las formas en que opera un racismo institucional a partir de discriminaciones explícitas; y las agencias y resistencias llevadas a cabo por personas racializadas.(AU)

Chile diversified the migrant population, starting with the arrival of people from Latin Ameri-ca. This, still far from being statistically significant, has generated a proliferation of negative social imaginaries, institutionally consolidated through restrictive approaches towards certain foreign groups.Institutional racism is reflected in policies and practices, placing migrant bodies in positions of inequality. Through qualitative research carried out in the XI region of Aysén (Chile), and through an intersectional analysis, we present the ways in which different inequalities —such as national origin, class and gender are articulated —in access and care in public health. The results show the existence of institutional racist practices and the imaginaries of “otherness”; the ways in which institutional racism operates based on explicit discrimination; and the agen-cies and resistance carried out by racialized people.(AU)