ABSTRACT
Male pseudohermaphroditism and androgen insensitivity syndrome cases have an increased risk of developing testicular cancer due to many factors such as mutations, hormonal disturbances involving gonadotropins and cryptorchidism. We describe the clinical features, diagnosis and treatment of two cases with partial androgen insensitivity syndrome and testicular cancer development, which were handled at the National Cancer Institute of Mexico.
Subject(s)
Androgen-Insensitivity Syndrome/diagnosis , Neoplasms, Germ Cell and Embryonal/diagnosis , Testicular Neoplasms/diagnosis , Adult , Androgen-Insensitivity Syndrome/complications , Cryptorchidism/complications , Disorders of Sex Development/complications , Female , Humans , Male , Mexico , Middle Aged , Neoplasms, Germ Cell and Embryonal/complications , Population , Testicular Neoplasms/complicationsABSTRACT
We present 4 case studies of patients with Down's syndrome and testicular germ-cell cancer, treated with conventional methods at the National Cancer Institute of Mexico, with similar outcomes as patients without this syndrome. There are several reports of testicular cancer arising in patients with Down's syndrome worldwide, mainly from Caucasian populations. We discuss some theories about the association and the possible increase of incidence.
