[The effect of valproic acid on sleep structure and ethanol consumption in rats with various types of individual reactivity before and after stress exposure]. / Vliianie val'proevoi kisloty na strukturu sna i potreblenie étanola u krys s razlichnymi tipami individual'noi reaktivnosti do i posle stressornogo vozdeistviia.

The influence of valproic acid on sleep structure and alcohol motivation was studied in pretyped rats prior and following REM sleep deprivation. During EEG recording of wake-sleep cycle valporoic acid was shown to produce hypnotic action dependent on drug dosage in high active and low active animals. There was also shown that following REM sleep deprivation low active animals significantly reduced ethanol consumption under valproic acid influence. It seems likely from the results obtained that valproic acid could be used as hypnotic and antialcoholic drug.