The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations.

Hypertension results from the interaction of genetic and acquired factors. IgG occurs in the form of different subclasses, of which the effector functions show significant variation. The detailed differences between the glycosylation profiles of the individual IgG subclasses may be lost in a profiling method for total IgG N-glycosylation. In this study, subclass-specific IgG Fc glycosylation profile was investigated in the four northwestern Chinese minority populations, namely, Uygur (UIG), Kazak (KZK), Kirgiz (KGZ), and Tajik (TJK), composed of 274 hypertensive patients and 356 healthy controls. The results showed that ten directly measured IgG N-glycan traits (i.e., IgG1G0F, IgG2G0F, IgG2G1FN, IgG2G1FS, IgG2G2S, IgG4G0F, IgG4G1FS, IgG4G1S, IgG4G2FS, and IgG4G2N) representing galactosylation and sialylation are significantly associated with hypertension, with IgG4 consistently showing weaker associations of its sialylation, across the four ethnic groups. We observed a modest improvement on the AUC of ROC curve when the IgG Fc N-glycan traits are added into the glycan-based model (difference between AUCs, 0.044, 95% CI: 0.016-0.072, P = 0.002). The AUC of the diagnostic model indicated that the subclass-specific IgG Fc N-glycan profiles provide more information reinforcing current models utilizing age, gender, BMI, and ethnicity, and demonstrate the potential of subclass-specific IgG Fc N-glycosylation profiles to serve as a biomarker for hypertension. Further research is however required to determine the additive value of subclass-specific IgG Fc N-glycosylation on top of biomarkers, which are currently used.

[Brain concussion--a minor craniocerebral injury]. / Potres mozga--laka kraniocerebralna povreda.

INTRODUCTION: Brain concussion is a brain dysfunction without any macroscopic structural damage, caused by mechanical force. This research paper presents the occurrence and basic characteristics of patients with brain concussion without skull fracture. The second aim of this paper is to answer questions, related to this problem, neurosurgeons are most often asked by doctors of other specialties. MATERIAL AND METHODS: Posttraumatic amnesia (patient unable to remember events before and/or after injury) was a condition to diagnose the brain concussion. In 1995 there were 240 patients with brain concussions without skull fracture at the Department of Urgent Surgery of our Institute. Eighty of them (33%) have been admitted to the Neurosurgical Clinic for observation and/or treatment. In all patients with brain concussion the following diagnostic procedure was applied: personal history, physical and neurological examination, basic blood tests and skull x-rays. CT imaging of the brain is not a routine because of our economic and technical circumstances. RESULTS: 240 patients were examined; 67% were males. Glasgow coma score (GSC) was 13-15 in all patients, while in nonhospitalized patients it was 15 (GSC = 15). 54% of patients were 15-40 years old; 35% were 41-60 years old and 11% were older than 60 years of age. Average hospitalization lasted for 3.48 days. According to the Glasgow outcome scale all patients had a good recovery. DISCUSSION: Patients with brain concussion have always amnesia with normal neurologic status. Legal and clinical definition of the minor head injury are not completely equal. Brain concussion is legally always a minor head injury. Patients with organic damage of brain (legally severe injury) can clinically look like having minor injury initially or till the end of the illness. Risk for brain damage in patients with amnesia is about 3%. Posttraumatic amnesia is always established by asking patients to remember events and not asking them if they were unconscious. Brain concussion is often associated with headache, vegetative or/and psychotic difficulties. Diagnostic protocol should comprise at least personal history, physical and neurological examination and skull x-ray. Consultation of a neurosurgeon and hospitalization are not indicated in all cases. In our series it was done in 33% according to indications which are established. In these cases patients should be transported with documents describing the type of injury, diagnostic results and treatment performed. The therapy is symptomatic. After brain concussion gradual return to everyday activities is indicated. Sick leave of 7-10 days is usually sufficient. Postconcussion syndrome (headache, vegetative or psychotic disturbances) occurs often and may last for a long period of time. CONCLUSION: We tried to describe a doctrine for diagnostic and treatment of patients suffering from brain concussion most appropriate according to our technical and economical circumstances.

[Expansive processes in the optic chiasm region]. / Ekspanzivni procesi optohijazmatske regije.

81 patients with expansive lesion in the optic chiasm region were reviewed. Pituitary adenomas were diagnosed in 37 patients: 5 with acromegaly, 2 with prolactinoma and the remaining 30 with hormone inactive adenomas. Meningiomas were diagnosed in 39, craniopharyngiomas in 4 patients and chordoma in one patient. The most common symptom was visual disturbance in 86%, but headache, hormonal disturbance occurred as well. All patients with adenomas were endocrinologically evaluated after detailed ophthalmologic and neurologic examinations. 28 patients were transcranially operated, 5 transsfenoidally and transcranially and 4 only transfenoidally. After endocrinologic reevaluation all patients with adenomas had undergone postoperative radiotherapy. Tumor recurrence was diagnosed in 14 patients, while 6 patients underwent reoperation. The approach to surgical regimen depended on the size and localization of meningioma. Unilateral subfrontal approach was most frequent (35). Subtotal tumor ablation was performed in 5 (13%) patients. Craniopharyngiomas were diagnosed in 4 patients (2 adults and 2 children). Total tumor ablation was performed only in one case.

[Surgical treatment of compressive lumbar radiculopathy]. / Operativno lecenje kompresivne lumbalne radikulopatije.

In the period 1982-1991, 1511 patients with compressive degenerative lumbar radiculopathy underwent surgery at the Clinic of Neurosurgery in Novi Sad. 1053 patients (69.69%) were operated due to radiculopathy of herniated disc etiology, 83 patients (5.50%) because od spondylotic radiculopathy and 38 patients (2.51%) because of spinal stenosis. 327 patients (21.64%) underwent surgery due to associated lesions, while 10 (0.66%) were operated because of other lesions. In patients with isolated disc herniations either interhemilaminectomy or extirpation of the degenerated pulp nuclei was performed, while in patients with spondylotic and stenotic radiculopathies most often decompressive laminectomy with facectomy and foraminatomy were performed. In cases of combined lesions combined surgical procedures were performed. There was no perioperative mortality. In 5 operated patients (0.33%) nonsurgical complications occurred, such as thrombophlebitis. Reoperation was performed in 94 patients (6.22%). Wound infection occurred in 4 patients (0.26%) and liquor fistula in 3 patients (0.20%). The paper presents diagnostic procedures, indications for surgical treatment and strategies.

[Early aggressive treatment in severe craniocerebral injuries]. / Rani agresivni tretman teske kraniocerebralne povrede.

A series of 33 severely head injured patients, Glasgow Coma Scala score 8 or less, was studied prospectively. All patients were treated by the same protocols and by the physician. Intracranial pressure was monitored in all patients by ventricular puncture. Some degree of increased intracranial pressure (more than 10mmHg) was present at admission to the intensive care unit in 52% of cases. Increases in over 20mmHg during the monitoring period were seen in 15 patients (45%). In 5 patients (15%) he was over 20mmHg, but controlled in intensive care unit with combination of dexamethasone, hyperventilation, normothermia, furosemide and mannitol. In this group mortality rate was 80%. In 10 patients (30%) intracranial hypertension was uncontrollable despite intensive measures, in this group all patients died. The mortality rate in patients with intracranial pressure less than 20mmHg during the monitoring period was significantly lower, 25%. Uncontrollable intracranial hypertension is a serious prognostic sign; all affected patients in our series died. Even intracranial pressure more than 20mmHg, which could be controlled, was associated with high mortality rate (80%). By early aggressive treatment based on intracranial pressure monitoring we can diminish the incidence of intracranial hypertension and reduce overall mortality rate in patients with severe head injury.

[A completely organized extracerebral hematoma--case report]. / Potpuno organizov an ekstracerebralni hematom--prikaz slucaja.

Extracerebral hematomas, mostly caused by trauma, can be epidural or subdural according to their localization. According to their clinical picture they can be acute, subacute or chronic. Chronic epidural hematomas are extremely rare cases. Extracerebral hematomas are hemolyzed with time and fibrosis happens around them and, if not operated, they may appear finally as dural scars. Diagnostic and evolution of these hematomas can be presented by CT of the brain. They can be differential diagnostic problem in diagnosis of tumor of cranial bone, dura mater or brain. Definitive diagnosis is accomplished by pathoanatomic and pathohistologic examination. Treatment of these hematomas is mostly operative. This paper deals with a patient who suffered of completely organized dural scar that is very rare.

[Treatment of penetrating craniocerebral injuries from the Vukovar conflict, 1991-1992. Analysis of a series]. / Lecenje penetrantnih kraniocerebralnih povreda s Vukovarskog ratista, 1991-1992. Analiza serije.

Throughout the course of Vukovar conflict from July, 1991, to May, 1992, there were 37 patients with war craniocerebral injuries evacuated to our Clinic. 29 patients suffered penetrating missile craniocerebral injuries, in 14 (48%) there were fragment wounds and in 15 (52%) gunshot wounds. The series was analyzed according to wounding agents, sites of head penetration, CT scan findings, neurological findings, operative and postoperative complications, and mortality. We have found significant difference in mortality between wounded who sustained fragment wounds (14%) and those with gunshot wounds (27%). Further we emphasize the necessity of CT scanning, concerning a high haematoma incidence of 27 percent. Presence of retained in-driven bone or metal fragments in our series had no influence on development of either seizure disorder or an infectious complication. This supports a thesis of a limited brain debridement as a correct approach in the treatment of penetrating missile injuries.