1.
Bioorg Med Chem Lett
; 16(2): 297-301, 2006 Jan 15.
Article
in English
| MEDLINE
| ID: mdl-16275080
ABSTRACT
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.
Subject(s)
Acetates/pharmacology , Oxazoles/chemistry , PPAR alpha/agonists , PPAR gamma/agonists , Acetates/administration & dosage , Acetates/chemical synthesis , Administration, Oral , Animals , Blood Glucose/drug effects , Cholesterol, HDL/blood , Cholesterol, HDL/drug effects , Drug Evaluation, Preclinical , Ligands , Mice , Mice, Mutant Strains , Mice, Obese , Molecular Structure , PPAR alpha/metabolism , PPAR gamma/metabolism , Structure-Activity Relationship , Triglycerides/blood , Triglycerides/metabolism
2.
Bioorg Med Chem Lett
; 14(3): 783-6, 2004 Feb 09.
Article
in English
| MEDLINE
| ID: mdl-14741289
ABSTRACT
Bis-aryl ureas have been disclosed previously as a potent class of Raf kinase inhibitors. Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug. Based on this finding, we hypothesize that this portion of the molecule is directed towards the solvent in Raf-1.