Subject(s)
Aorta, Abdominal/abnormalities , Aorta, Thoracic/abnormalities , Arteries/abnormalities , Blood Pressure , Hypertension, Renovascular/etiology , Joint Instability/complications , Renal Artery Obstruction/etiology , Renal Artery/abnormalities , Skin Diseases, Genetic/complications , Vascular Malformations/complications , Aorta, Abdominal/diagnostic imaging , Aorta, Abdominal/physiopathology , Aorta, Thoracic/diagnostic imaging , Aorta, Thoracic/physiopathology , Aortography/methods , Arteries/diagnostic imaging , Arteries/physiopathology , Child, Preschool , Computed Tomography Angiography , Genetic Predisposition to Disease , Genetic Variation , Glucose Transport Proteins, Facilitative/genetics , Humans , Hypertension, Renovascular/diagnosis , Hypertension, Renovascular/physiopathology , Joint Instability/diagnostic imaging , Joint Instability/genetics , Joint Instability/physiopathology , Male , Phenotype , Renal Artery/diagnostic imaging , Renal Artery/physiopathology , Renal Artery Obstruction/diagnostic imaging , Renal Artery Obstruction/physiopathology , Severity of Illness Index , Skin Diseases, Genetic/diagnostic imaging , Skin Diseases, Genetic/genetics , Skin Diseases, Genetic/physiopathology , Vascular Malformations/diagnostic imaging , Vascular Malformations/genetics , Vascular Malformations/physiopathologyABSTRACT
BACKGROUND: Mycoplasma pneumoniae can cause various extrapulmonary manifestations but, to our knowledge, no case of Mycoplasma pneumoniae associated with hemolytic uremic syndrome (HUS) has been reported. CASE-DIAGNOSIS/TREATMENT: We describe a 1-year-old boy with M. pneumoniae respiratory tract infection and associated microangiopathic hemolytic anemia, slightly decreased platelet count and mild renal impairment, suggesting a diagnosis of HUS. Assuming M. pneumoniae infection was the cause of HUS in this case, the different possible mechanisms, including an atypical HUS due to preexisting complement dysregulation, an alternative complement pathway activation induced by M. pneumoniae infection at the acute phase, an autoimmune disorder, and a direct role of the bacteria in inducing endothelial injury, are discussed. The signs of HUS resolved with treatment of the M. pneumoniae infection. CONCLUSIONS: Hemolytic uremic syndrome may be an unusual complication of M. pneumoniae infection.
