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1.
Rev. neurol. (Ed. impr.) ; 57(7): 313-316, oct. 2013. ilus
Article in Spanish | IBECS | ID: ibc-116292

ABSTRACT

Introducción. El dolor neuropático es una entidad que no se conoce bien. Afecta a un porcentaje significativo de la población. Su principal problema radica en que puede llegar a ser una patología bastante invalidante. El tratamiento principal se basa fundamentalmente en dos fármacos: gabapentina y pregabalina. Otros fármacos, como los antidepresivos, los opioides o los antagonistas de receptores de N-metil D-aspartato también pueden utilizarse en combinación con los fármacos principales. A pesar de esto, el tratamiento es poco satisfactorio. Además, debe considerarse que pueden existir pacientes que presenten alergia a los dos fármacos principales. Caso clínico. Mujer de 36 años, afecta de dolor neuropático secundario a una cirugía de neurinoma del plexo braquial, cuyo tratamiento con gabapentina o pregabalina no era posible por tener antecedentes personales de alergia. Sin embargo, el tratamiento con otro fármaco (lacosamida) resultó muy efectivo, al presentar muy buena respuesta. Conclusión. La lacosamida es un fármaco antiepiléptico de tercera generación, eficaz, seguro y con pocos efectos secundarios. Se ha considerado una buena opción terapéutica para el tratamiento del dolor neuropático en pacientes alérgicos a la pregabalin (AU)


Introduction. Neuropathic pain is a condition that is still not well understood, although it affects a significantly high percentage of the population. The main problem lies in the fact that it can become a fairly disabling pathology. Themost frequent treatment is based essentially on two drugs: gabapentin and pregabalin. Other pharmaceuticals, such as antidepressants, opioids or N-methyl-D-aspartate receptor antagonists can also be employed in combination with the primary drugs. All the same, treatment remains unsatisfactory. Furthermore, it must be borne in mind that there may be patients who are allergic to the two main drugs. Case report. We report the case of a 36-year-old female with neuropathic pain secondary to surgery to correct a neurinoma in the brachial plexus, who could not be treated with gabapentin or pregabalin because of a personal history of allergy to these substances. Treatment with another drug (lacosamide), however, was very effective and displayed a very good response. Conclusions. Lacosamide is a third-generation antiepileptic drug that has been proven to be effective, safe and with few side effects. It has been considered a good therapeutic option for the treatment of neuropathic pain in patients who are allergic to pregabalin (AU)


Subject(s)
Humans , Female , Adult , Anticonvulsants/therapeutic use , Pain/drug therapy , Neuralgia/drug therapy , Pain, Postoperative/drug therapy , Drug Hypersensitivity/complications , Brachial Plexus/surgery
2.
Rev Neurol ; 57(7): 313-6, 2013 Oct 01.
Article in Spanish | MEDLINE | ID: mdl-24052442

ABSTRACT

INTRODUCTION: Neuropathic pain is a condition that is still not well understood, although it affects a significantly high percentage of the population. The main problem lies in the fact that it can become a fairly disabling pathology. The most frequent treatment is based essentially on two drugs: gabapentin and pregabalin. Other pharmaceuticals, such as antidepressants, opioids or N-methyl-D-aspartate receptor antagonists can also be employed in combination with the primary drugs. All the same, treatment remains unsatisfactory. Furthermore, it must be borne in mind that there may be patients who are allergic to the two main drugs. CASE REPORT: We report the case of a 36-year-old female with neuropathic pain secondary to surgery to correct a neurinoma in the brachial plexus, who could not be treated with gabapentin or pregabalin because of a personal history of allergy to these substances. Treatment with another drug (lacosamide), however, was very effective and displayed a very good response. CONCLUSIONS: Lacosamide is a third-generation antiepileptic drug that has been proven to be effective, safe and with few side effects. It has been considered a good therapeutic option for the treatment of neuropathic pain in patients who are allergic to pregabalin.


TITLE: Lacosamida como alternativa en el tratamiento del dolor neuropatico posquirurgico en una paciente alergica.Introduccion. El dolor neuropatico es una entidad que no se conoce bien. Afecta a un porcentaje significativo de la poblacion. Su principal problema radica en que puede llegar a ser una patologia bastante invalidante. El tratamiento principal se basa fundamentalmente en dos farmacos: gabapentina y pregabalina. Otros farmacos, como los antidepresivos, los opioides o los antagonistas de receptores de N-metil D-aspartato tambien pueden utilizarse en combinacion con los farmacos principales. A pesar de esto, el tratamiento es poco satisfactorio. Ademas, debe considerarse que pueden existir pacientes que presenten alergia a los dos farmacos principales. Caso clinico. Mujer de 36 años, afecta de dolor neuropatico secundario a una cirugia de neurinoma del plexo braquial, cuyo tratamiento con gabapentina o pregabalina no era posible por tener antecedentes personales de alergia. Sin embargo, el tratamiento con otro farmaco (lacosamida) resulto muy efectivo, al presentar muy buena respuesta. Conclusion. La lacosamida es un farmaco antiepileptico de tercera generacion, eficaz, seguro y con pocos efectos secundarios. Se ha considerado una buena opcion terapeutica para el tratamiento del dolor neuropatico en pacientes alergicos a la pregabalina.


Subject(s)
Acetamides/therapeutic use , Analgesics/therapeutic use , Anticonvulsants/therapeutic use , Brachial Plexus Neuropathies/drug therapy , Drug Hypersensitivity/complications , Neuralgia/drug therapy , Pain, Postoperative/drug therapy , Adult , Amines , Brachial Plexus Neuropathies/etiology , Contraindications , Cyclohexanecarboxylic Acids , Drug Hypersensitivity/etiology , Female , Gabapentin , Humans , Lacosamide , Magnetic Resonance Imaging , Neuralgia/etiology , Neurofibroma/complications , Neurofibroma/surgery , Pain, Postoperative/etiology , Peripheral Nervous System Neoplasms/complications , Peripheral Nervous System Neoplasms/surgery , Pregabalin , gamma-Aminobutyric Acid/analogs & derivatives
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