1.
Drug Metab Dispos
; 19(5): 1012-3, 1991.
Article
in English
| MEDLINE
| ID: mdl-1686225
Subject(s)
Amobarbital/metabolism , Animals , Cats , Female , Glycosylation , In Vitro Techniques , Male , Microsomes, Liver/metabolism , Stereoisomerism
2.
Pharm Res
; 7(4): 402-6, 1990 Apr.
Article
in English
| MEDLINE
| ID: mdl-2362916
ABSTRACT
The absolute configuration of the N-beta-D-glucoside metabolites of phenobarbital was determined by methylation of the diastereomers to make mephobarbital N-beta-D-glucosides, followed by oxidative removal of glucose to give the optical isomers of mephobarbital. Following a single oral dose of phenobarbital to two male subjects, both phenobarbital N-beta-D-glucosides were excreted in the urine. The absolute configuration (C-5 position) of the major phenobarbital N-beta-D-glucoside excreted in the urine was the S form. A pronounced stereoselective formation and/or urinary excretion occurs for the N-glucoside conjugates of phenobarbital in humans.