ABSTRACT
Antipancreas autoimmunity is one of several immunity problems in diabetes. Such of its features as are revealed by inhibition of leukocyte migration, lymphocyte transformation in response to insulin antigens, relation between cell autoimmunity and later complications, and the behaviour of peripheral T and B lymphocyte membrane markers are explained. The aetiological role of viral infections is discussed, and the pathogenetic hypothesis deducible from the histological findings. Lastly, the modalities underlying a combination between the HLA (human leukocyte antigen) system and diabetes are considered.
Subject(s)
Autoantibodies/analysis , Diabetes Mellitus/immunology , Pancreas/immunology , Antigens/adverse effects , B-Lymphocytes , Humans , Leukocyte Count , Leukocyte Migration-Inhibitory Factors , Leukocytes/immunology , Lymphocyte Activation , Lymphocytes/immunology , T-LymphocytesABSTRACT
The behaviour of HBsAg and hepatitis B in 86 patients and in 24 medical personnel of a hemodialysis Center during 5 years is described. Hepatitis B antigen was detected in 28 patients (32.55%); hepatitis B infection developed in 7 of them and in 2 of the medical staff. Some problems of prevention and therapy are discussed.