ABSTRACT
INTRODUCTION: Thyroid autoimmune diseases have been associated with a variety of rheumatologic diseases, including systemic lupus erythematosus (SLE). OBJECTIVE: To estimate the prevalence of thyroid autoimmune diseases in patients with SLE. METHODS: Transversal study to compare the prevalence of thyroid disorders in 106 patients with SLE and a control group of 102 patients. The patients were submitted to a clinical and a laboratorial evaluation; the tests included antiperoxidase and antithyroglobulin antibodies, TSH, free T4 and T3. RESULTS: We detected high prevalence of subclinical hypothyroidism (11%) and clinical hypothyroidism (13%) in the group of patients with SLE when they were compared to the control group, 7% and 1%, respectively (p < 0.001). The hyperthyroidism occurred in a same frequency in the two groups. The positivity of antithyroid antibodies was higher in the group with SLE (23% versus 19%, p = 0.025). The relative risk of the patients with SLE to develop thyroid dysfunctions was 1,6. CONCLUSION: The thyroid disorders were more prevalent in patients with LES than in general population.
Subject(s)
Lupus Erythematosus, Systemic/complications , Thyroiditis, Autoimmune/epidemiology , Adult , Age Distribution , Aged , Brazil/epidemiology , Case-Control Studies , Chi-Square Distribution , Cross-Sectional Studies , Female , Humans , Hyperthyroidism/complications , Hyperthyroidism/epidemiology , Hypothyroidism/complications , Hypothyroidism/epidemiology , Male , Middle Aged , Sex Distribution , Statistics, Nonparametric , Thyroiditis, Autoimmune/complications , Young AdultABSTRACT
INTRODUÇÃO: As doenças tireoidianas auto-imunes têm sido associadas com inúmeras desordens reumatológicas, incluindo o lúpus eritematoso sistêmico (LES). OBJETIVO: Avaliar a prevalência de alterações tireoidianas em pacientes com LES. MÉTODOS: Estudo de coorte transversal comparando prevalência de alterações tireoidianas em 106 pacientes com LES e grupo-controle de 102 pacientes. Os pacientes foram submetidos à avaliação clínica e laboratorial, com dosagens de anticorpos anti-TPO e anti-Tg, TSH, T4 livre e T3. RESULTADOS: Detectou-se aumento de prevalência de hipotireoidismo subclínico (11 por cento) e clínico (13 por cento) no grupo de pacientes com LES, comparados a 7 por cento e 1 por cento, respectivamente, no grupo-controle (p < 0,001). Não houve diferença de prevalência de hipertireoidismo entre os grupos comparados. A positividade de anticorpos antitireoidianos foi maior no grupo de LES (23 por cento versus 19 por cento, p = 0,025). O risco relativo de pacientes com LES apresentarem alterações tireoidianas foi de 1,60. CONCLUSÃO: As alterações tireoidianas são mais freqüentes em pacientes com LES que na população geral.
INTRODUCTION: Thyroid autoimmune diseases have been associated with a variety of rheumatologic diseases, including systemic lupus erythematosus (SLE). OBJECTIVE: To estimate the prevalence of thyroid autoimmune diseases in patients with SLE. METHODS: Transversal study to compare the prevalence of thyroid disorders in 106 patients with SLE and a control group of 102 patients. The patients were submitted to a clinical and a laboratorial evaluation; the tests included antiperoxidase and antithyroglobulin antibodies, TSH, free T4 and T3. RESULTS: We detected high prevalence of subclinical hypothyroidism (11 percent) and clinical hypothyroidism (13 percent) in the group of patients with SLE when they were compared to the control group, 7 percent and 1 percent, respectively (p < 0,001). The hyperthyroidism occurred in a same frequency in the two groups. The positivity of antithyroid antibodies was higher in the group with SLE (23 percent versus 19 percent, p = 0,025). The relative risk of the patients with SLE to develop thyroid dysfunctions was 1,6. CONCLUSION: The thyroid disorders were more prevalent in patients with LES than in general population.
