[Prognostic significance of osseous lesions in acute lymphoblastic leukemia in children]. / Il significato prognostico delle lesioni ossee nella leucemia acuta linfoblastica del bambino.

Full skeletal survey was performed on 54 children presenting over a 6-year period (1973-1979) with acute lymphoblastic leukaemia (ALL). Findings that were considered attributable to leukaemia included metaphyseal bands, osteolytic lesions and periosteal reactions. One or more of these roentgenographic findings was observed in 24 children (44%). The mean duration of remission and of survival was much shorter in cases with multiple bone involvement (3 or more lesions) than in those where bone involvement was absent or limitated at 1 or 2 bone lesions.

[Skeletal changes in Wolf's syndrome (4p--) and in Klinefelter quadrisomy (author's transl)]. / Alterazioni scheletriche nella sindrome wolfiana (4p--) e nella quadrisomia di Klinefelter.

Clinical-genetic research is at present foundamental to the diagnosis of diseases caused by cromosome abnormalities. Radiologic investigation is necessary to complete the diagnosis evincing morphologic and skeletric changes peculiar to each disease.