ABSTRACT
Avaliar a atividade de Chondrodendronplatyphyllum sobre o sistema nervoso central. Material eMétodos: Realizou-se testes gerais para avaliar o efeito dafração total de alcalóides sobre o SNC. A FTA nas doses de100, 200 e 400 mg/kg foi administrada em camundongos porvia i.p e foi realizado uma triagem farmacológica experimental,na qual foi avaliada a mudança comportamental dosanimais. No teste da potencialização do tempo de sonobarbitúrico, o pentobarbital sódico (PTB) 40 mg/kg, via i.p.,foi administrado trinta minutos após da solução de FTA 200mg/kg e os parâmetros observados neste teste foram: latênciae tempo de sono. Também foi avaliada a coordenação motorados animais tratados com FTA 200 mg/kg, no teste do rotarod,foram considerados aptos os animais que permaneceramna barra giratório por 180s. Resultados: Os resultadosobtidos por meio da triagem farmacológica demonstram queesta fração possui uma atividade no sistema nervoso centrale que possivelmente esta atividade é depressora. Otratamento com a FTA não interferiu na latência e nem notempo de sono induzido pelo PTB. A FTA não tem nenhumefeito miorrelaxante e não interfere na coordenação motorados animais submetidos ao rota-rod. Conclusão: AChondrodendron platyphyllum exerce um efeito no SNC...
To evaluate the activity of Chondrodendronplatyphyllum on CNS. Material and Methods: Were performedgeneral tests to assess the effect of the TAF on the CNS.The TAF in doses of 100, 200 and 400 mg / kg wasadministered to mice by intraperitoneal route and apharmacological screening trial was carried out, whichevaluated the behavioral change of the animals. In the test ofpotentiation of barbiturate sleeping time, sodium pentobarbital(PTB) 40 mg / kg, ip, was administered thirty minutes afterthe TAF solution of 200 mg / kg. The parameters observed inthis trial were: latency and sleep time. Were also evaluatedthe motor coordination of the animals treated with TAF 200mg / kg in the rota-rod test. The animals considered fit werethose which remained in the revolving bar for 180s. Results:The results obtained by pharmacological screening showedthat this fraction has an activity in the central nervous systemand possibly that this activity is depressing. The treatmentdid not interfere either with the TAF in latency or with the timeof sleep induced by PTB. The TAF has no myorelaxing effectand doesnt interfere with motor coordination of the animalssubjected to rota-rod. Conclusion: Chondrodendronplatyphyllum exerts a depressant effect on CNS...
Subject(s)
Mice , Plants, Medicinal , Central Nervous System , Pain MeasurementABSTRACT
AIM OF THE STUDY: Aniba rosaeodora is an aromatic plant which has been used in Brazil folk medicine due to its sedative effect. Therefore, the purpose of the present study was to evaluate the sedative effect of linalool-rich rosewood oil in mice. In addition we sought to investigate the linalool-rich oil effects on the isolated nerve using the single sucrose-gap technique. MATERIALS AND METHODS: Sedative effect was determined by measuring the potentiation of the pentobarbital-induced sleeping time. The compound action potential amplitude was evaluated as a way to detect changes in excitability of the isolated nerve. RESULTS: The results showed that administration of rosewood oil at the doses of 200 and 300 mg/kg significantly decreased latency and increased the duration of sleeping time. On the other hand, the dose of 100 mg/kg potentiated significantly the pentobarbital action decreasing pentobarbital latency time and increasing pentobarbital sleeping time. In addition, the effect of linalool-rich rosewood oil on the isolated nerve of the rat was also investigated through the single sucrose-gap technique. The amplitude of the action potential decreased almost 100% when it was incubated for 30 min at 100 microg/ml. CONCLUSIONS: From this study, it is suggested a sedative effect of linalool-rich rosewood oil that could, at least in part, be explained by the reduction in action potential amplitude that provokes a decrease in neuronal excitability.
