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1.
Glob Chang Biol ; 27(3): 576-586, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33063896

ABSTRACT

The swap in abundance between two Calanus species in the North Sea during the 1980s constitutes a quintessential example of regime shift, with important ecosystemic and economic repercussions because these copepods constitute a major component of the diet of larval and juvenile cods. It is hypothesized that this transition was driven by gradual changes in primary productivity, the North Atlantic Oscillation (NAO) and sea surface temperatures (SST), and yet how these factors contribute to the population dynamics of these two species and the overall regime shift remains unclear. Here, we combine a highly resolved and spatially structured longitudinal dataset with population dynamics theory-based models to obtain a thorough and more detailed description of populations' responses to the regime shift observed in the North Sea. Our analyses highlight that this transition exhibits a clear spatial structure and involved a decoupling between the dynamics of Calanus finmarchicus and the NAO in western regions and between Calanus helgolandicus and SST in the eastern regions of the North Sea. Consequently, the observed switch in abundance between these species reflects the interaction between species-specific attributes, a well-defined spatial structure with a marked east-west axis and a decoupling between the ecological drivers and Calanus population dynamics following the shift. Succinctly, we suspect that higher water temperatures have favored C. helgolandicus and resulted in restrictive conditions for C. finmarchicus, eventually overshadowing the effects of NAO detected in historical records. Overall, our study illustrates how population dynamics theory can be successfully employed to disentangle the complex and multifactorial nature of a regime shift in response to gradually changing environmental conditions.


Subject(s)
Copepoda , Animals , Ecosystem , North Sea , Population Dynamics , Temperature
2.
Popul Health Manag ; 22(5): 422-432, 2019 10.
Article in English | MEDLINE | ID: mdl-30562144

ABSTRACT

This qualitative review of 57 published case reports aimed to analyze primary care and public health integration efforts in 45 states to summarize collaboration aims, participants, and systemic, organizational, and interactional success determinants. Chronic disease management, maternal and child health, and wellness and health promotion were the most commonly reported aims of collaboration between primary care and public health entities in the United States. Typical participants were government public health structures, health delivery systems, communities, academia, state professional medical associations, and employers and businesses. Systemic, organizational, and interactional determinants included adequate funding, multiple stakeholder engagement, leadership, data and information sharing, capitalization on collaborator resources, community engagement, steering committees, effective communication, regular meetings, shared mission, vision, and goals, previous positive relationships, collaborations, and partnerships. The present study contributes to the body of knowledge of when, where, and under what contextual circumstances collaboration and integration have been perceived as effective. Future research could extrapolate which determinants are more essential than others and focus on how systemic, organizational, and interactional factors are interrelated. To advance the practice of successful integration between primary care and public health entities, longitudinal research is needed to examine the degree of integration and sustainability.


Subject(s)
Cooperative Behavior , Primary Health Care , Public Health , Research Report , Databases, Factual , Female , Humans , Male , Qualitative Research , United States
3.
Clin Infect Dis ; 67(6): 845-853, 2018 08 31.
Article in English | MEDLINE | ID: mdl-29767683

ABSTRACT

Background: In May 2012, the New Hampshire (NH) Division of Public Health Services (DPHS) was notified of 4 persons with newly diagnosed hepatitis C virus (HCV) infection at hospital X. Initial investigation suggested a common link to the hospital cardiac catheterization laboratory (CCL) because the infected persons included 3 CCL patients and a CCL technician. NH DPHS initiated an investigation to determine the source and control the outbreak. Methods: NH DPHS conducted site visits, case patient and employee interviews, medical record and medication use review, and employee and patient HCV testing using enzyme immunoassay for anti-HCV, reverse-transcription polymerase chain reaction for HCV RNA, nonstructural 5B (NS5B) and hypervariable region 1 (HVR1) sequencing, and quasispecies analysis. Results: HCV HVR1 analysis of the first 4 cases confirmed a common source of infection. HCV testing identified 32 of 1074 CCL patients infected with the outbreak strain, including 3 patients coinfected with >1 HCV strain. The epidemiologic investigation revealed evidence of drug diversion by the HCV-infected technician, evidenced by gaps in controlled medication control, higher fentanyl use during procedures for confirmed cases, and building card key access records documenting the presence of the technician during days when transmission occurred. The employee's status as a traveling technician led to a multistate investigation, which identified additional cases at prior employment sites. Conclusions: This is the largest laboratory-confirmed drug diversion-associated HCV outbreak published to date. Recommendations to reduce drug diversion risk and to conduct outbreak investigations are provided.


Subject(s)
Cross Infection/epidemiology , Disease Outbreaks , Hepatitis C/epidemiology , Hepatitis C/etiology , Laboratories, Hospital , Medical Laboratory Personnel , Prescription Drug Diversion , Adult , Aged , Aged, 80 and over , Cross Infection/virology , Female , Genotype , Hepacivirus/genetics , Hepacivirus/isolation & purification , Hepatitis C/diagnosis , Humans , Male , Middle Aged , New Hampshire/epidemiology , Phylogeny , RNA, Viral/genetics , Sequence Analysis, DNA
5.
Pediatr Infect Dis J ; 27(3): 193-9, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18277925

ABSTRACT

BACKGROUND: Meningococcal disease is a serious problem in adolescents, including high school students. Universal immunization of adolescents with meningococcal conjugate vaccine was recently recommended. We studied risk factors for meningococcal disease in students in grades 9-12. METHODS: This was a matched case-control study using surveillance for meningococcal disease in students in grades 9-12 in sites throughout the United States. For each case-patient, up to 4 controls were selected from the home room classroom. All subjects answered an extensive questionnaire. Logistic regression was performed to identify risk factors associated with meningococcal disease. Meningococcal isolates were characterized. RESULTS: Of 69 eligible patients, 49 (71%) were enrolled and had at least 1 control. Isolates were available for 59 (86%) cases. Attending at least 1 barbeque or picnic [matched odds ratio (MOR): 0.26, P value = 0.003] or school dance (MOR: 0.30, P = 0.04) were independently associated with decreased risk of meningococcal disease. Male gender (MOR: 2.94, P = 0.009), upper respiratory infection symptoms (MOR: 2.43, P = 0.04), marijuana use (MOR: 4.21, P = 0.009), and nightclub/disco attendance (MOR: 3.30, P = 0.04) were associated with increased risk. Among 54 students not from Oregon (where serogroup B strains predominate) with available serogroup, 38 (73.1%) cases were potentially vaccine preventable: 18 (34.6%) serogroup C, 19 (36.5%) serogroup Y, and 1 (1.9%) serogroup W-135. CONCLUSIONS: Certain behaviors increase the risk of meningococcal infection, whereas others are associated with decreased risk. Most meningococcal disease in high school students can be prevented if recommendations on use of meningococcal conjugate vaccine are implemented.


Subject(s)
Meningitis, Meningococcal/epidemiology , Adolescent , Adult , Case-Control Studies , Humans , Logistic Models , Male , Neisseria meningitidis/classification , Neisseria meningitidis/isolation & purification , Respiratory Tract Infections/epidemiology , Risk Factors , Serotyping , Sex Factors , Social Behavior , Students , Substance-Related Disorders/epidemiology , Surveys and Questionnaires , United States/epidemiology
6.
Infect Control Hosp Epidemiol ; 28(9): 1093-5, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17932833

ABSTRACT

We surveyed hospital personnel regarding their preparedness to use and their actual use of portable isolation units that were distributed to increase facilities' capacity to place patients under airborne infection isolation precautions. Although personnel reported feeling prepared to use portable isolation units, the effectiveness of the unit deployment program would be enhanced by retrofitted rooms and an improved ability to monitor negative air pressure.


Subject(s)
Disaster Planning/methods , Disease Outbreaks/prevention & control , Infection Control/instrumentation , Patient Isolators/supply & distribution , Data Collection , Hospitals , Humans , New Hampshire , Quarantine
7.
Am J Prev Med ; 32(3): 239-43, 2007 Mar.
Article in English | MEDLINE | ID: mdl-17236744

ABSTRACT

BACKGROUND: As tuberculosis incidence declines in the United States, a new tool for TB control efforts is Mycobacterium tuberculosis genotyping. Colorado, Iowa, Montana, New Hampshire, West Virginia, and Wisconsin began routine genotyping of all culture-confirmed TB cases in October 2000. METHODS: M. tuberculosis isolates from cases reported October 2000 through December 2003 were genotyped by spoligotyping, mycobacterial interspersed repetitive units, and IS6110-based restriction fragment length polymorphism methods. Genotyping results were linked to demographic variables from national surveillance records. Patients who were in genotype clusters were interviewed and their records reviewed to determine possible transmission links among clustered patients. Final analysis was completed during April 2004 through June 2005. RESULTS: Of 971 reported TB cases, 774 (80%) were culture-confirmed, of which 728 (94%) were genotyped. Most genotyped isolates (634 [87%]) were unique. Within 36 clusters linking 94 individuals, four clusters involved both U.S.- and foreign-born individuals. For eight clusters, genotyping results led to the discovery of previously unsuspected transmission. Transmission links between individuals were established in 21 (58%) of the 36 clusters. CONCLUSIONS: In these six low-incidence states, most isolates had unique genotypes, suggesting that most cases arose from activation of latent infection. Few TB clusters involved the foreign-born. For 58% of genotype clusters, epidemiologic investigation ascertained that clustering represented recent M. tuberculosis transmission.


Subject(s)
Mycobacterium tuberculosis/genetics , Tuberculosis/microbiology , Cluster Analysis , Colorado/epidemiology , Genotype , Humans , Incidence , Iowa/epidemiology , Montana/epidemiology , Mycobacterium tuberculosis/isolation & purification , New Hampshire/epidemiology , Polymorphism, Restriction Fragment Length , Population Surveillance , Risk Assessment , Risk Factors , Tuberculosis/epidemiology , Tuberculosis/prevention & control , Tuberculosis/transmission , West Virginia/epidemiology , Wisconsin/epidemiology
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