ABSTRACT
One to 10% of the cases have cutaneous reactions caused by ampicillin. When this drug is associated to MI the percentage goes up to 90% of the cases. The physiopathogenic mechanism of the generalized exanthema in this association is unknown. The development of toxicity is postulated because these patients have no previous history of allergy to penicillin either before of after the cutaneous reaction. By a still obscure mechanism, MI predisposes or alters the patient sensibility to the drug and the cutaneous reaction appears. This picture cannot be attributed to MI because the exanthema that present is mild. Neither is this picture of allergy due to ampicillin, without relationship with the MI, because the reaction is not coincident with other descriptions of reactions by this drug. The clinic evidence, observed in patients with MI, and ampicillin, is of a strong relation between two factors and the cutaneous reaction. In our patient the eruption affected principally the sites exposed to the sun, that makes us think in a phototoxicity reaction. Despite this fact the tests done were negative. We agree with other authors that the administration of ampicillin in patients with ill-defined pharyngeal symptoms is contraindicated until infections mononucleosis is ruled out.
Subject(s)
Ampicillin/adverse effects , Drug Eruptions/etiology , Infectious Mononucleosis/drug therapy , Adult , Exanthema/chemically induced , Humans , Infectious Mononucleosis/complications , Male , Photosensitivity Disorders/chemically inducedABSTRACT
Dermatofibroma progressive and recurrent, described by Darier and Ferrand in 1924 is a tumour that grows slowly, and can invade the whole dermis, sectors of the conjunctival interlobular hypodermic tracts, superficial muscular fascia and invade striated muscular fibers, lymphatic ganglia and bones. The most frequent localization is the back and abdomen although it an be seen in other sits of the skin. Ulceration is not frequent. Usually it is most resistant to therapy and recidives frequently. As it is not radio sensible the treatment of first choice is surgery. The evolution is very slow, from months to twenty or more years. We communicate a case of dermatofibroma recurrent of Darier and Ferrand localized in the left supra spinal region, that ulcerated when patient was irradiated with cobalt because she had a lung adenocarcinoma. Possibility radiotherapy produced an alteration in the immunological state of the patient producing by this mechanism the ulceration of the DF.
Subject(s)
Fibroma/pathology , Skin Neoplasms/pathology , Female , Fibroma/surgery , Fibroma/ultrastructure , Humans , Microscopy, Electron , Middle Aged , Neoplasm Recurrence, Local , Skin Neoplasms/surgery , Skin Neoplasms/ultrastructureABSTRACT
Se presenta un caso de almohadillas articulares primarias con asiento en manos y pies en un paciente de 22 anos de edad. Es tratado con infiltraciones con corticoides sin resultados positivos. Se realizan comentarios con respecto a su clinica e histopatologia
Subject(s)
Adult , Humans , Male , Finger Joint , Joint DiseasesABSTRACT
Se presenta un caso de almohadillas articulares primarias con asiento en manos y pies en un paciente de 22 anos de edad. Es tratado con infiltraciones con corticoides sin resultados positivos. Se realizan comentarios con respecto a su clinica e histopatologia
