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Angew Chem Int Ed Engl
; 54(10): 2945-9, 2015 Mar 02.
Article
in English
| MEDLINE
| ID: mdl-25612560
ABSTRACT
Hydrofluoroethers are shown to alkylate tertiary amines readily under solvent-free conditions, affording valuable tetraalkylammonium perfluoroalkoxides bearing α-fluorines. The reaction of R(F)CF2-OCH3 (R(F)=CF2CF3, CF2CF2CF3, and CF(CF3)2) with NR(1)R(2)R(3) produces twenty new α-perfluoroalkoxides, [(CH3)NR(1)R(2)R(3)][R(F)CF2O] under mild conditions. These α-perfluoroalkoxides are easy to handle, thermally stable, and can be used for the perfluoroalkoxylation of benzyl bromides.
Subject(s)
Ammonium Compounds/chemistry , Fluorine/chemistry , Alkylation , Ethers/chemistry
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