ABSTRACT
Joint manifestation in Lyme disease hare shown similarities to those in reactive arthritis. SAPHO syndrome can also be included into the group of seronegative spondyloarthrophaties. It is presented a patient with joint, ocular and serological features proper of Lyme disease and after ones suggestive of SAPHO syndrome, who responds properly to an antibiotic treatment. It is considered the possibility that some patients suffering from SAPHO syndrome can also be suffering from Lyme disease.
Subject(s)
Lyme Disease/diagnosis , Adult , Eye Diseases/complications , Humans , Male , Psoriasis/complications , Spondylitis, Ankylosing/complications , SyndromeABSTRACT
A study is made of the state of cell and humoral immunity in parenteral drug addicts both with and without genital warts. The results reveal alterations in the lymphocyte subpopulations, with a decrease in the T-helper/T-suppressor (T4+/T8+) ratio of both groups of patients. These alterations were more pronounced in those patients with genital warts (p less than 0.05). The alterations in humoral immunity, expressed as a hypergammaglobulinemia IgG and IgM, were similar in both groups. None of the immunological parameters were affected by the extension of the lesions, though the T4+/T8+ ratio was found to decrease with increasing length evolution of the lesions. It would be convenient to perform longitudinal studies of these preliminary data to evaluate the effect of human papilloma virus (HPV) on the immune system.
Subject(s)
Condylomata Acuminata/immunology , Substance-Related Disorders/immunology , T-Lymphocytes/immunology , Adult , CD4-Positive T-Lymphocytes/immunology , Condylomata Acuminata/complications , Female , Humans , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Male , Substance-Related Disorders/complications , T-Lymphocytes, Helper-Inducer/immunology , T-Lymphocytes, Regulatory/immunologyABSTRACT
A study is made of the state of cell and humoral immunity in patients with genital warts. The results show an increase in the T-suppressor lymphocyte population (T8+) (p less than 0.011) of these patients, which reduces the T-helper/T suppressor ratio (T4 +/T8 +). No alterations are observed in the humoral immunity on analyzing seric immunoglobulin concentration (IgA, IgG, IgM), complement factors (C3, C4), or their functionality (CH50).
