Self-Supervised Monocular Depth Estimation With Positional Shift Depth Variance and Adaptive Disparity Quantization.

Recently, attempts to learn the underlying 3D structures of a scene from monocular videos in a fully self-supervised fashion have drawn much attention. One of the most challenging aspects of this task is to handle independently moving objects as they break the rigid-scene assumption. In this paper, we show for the first time that pixel positional information can be exploited to learn SVDE (Single View Depth Estimation) from videos. The proposed moving object (MO) masks, which are induced by the depth variance to shifted positional information (SPI) and are referred to as 'SPIMO' masks, are highly robust and consistently remove independently moving objects from the scenes, allowing for robust and consistent learning of SVDE from videos. Additionally, we introduce a new adaptive quantization scheme that assigns the best per-pixel quantization curve for depth discretization, improving the fine granularity and accuracy of the final aggregated depth maps. Finally, we employ existing boosting techniques in a new way that self-supervises moving object depths further. With these features, our pipeline is robust against moving objects and generalizes well to high-resolution images, even when trained with small patches, yielding state-of-the-art (SOTA) results with four- to eight-fold fewer parameters than the previous SOTA techniques that learn from videos. We present extensive experiments on KITTI and CityScapes that show the effectiveness of our method.

Respiratory muscle strength and cough capacity in patients with Duchenne muscular dystrophy.

The function of inspiratory muscles is crucial for effective cough as well as expiratory muscles in patients with Duchenne muscular dystrophy (DMD). However, there is no report on the correlation between cough and inspiratory muscle strength. To investigate the relationships of voluntary cough capacity, assisted cough techniques, and inspiratory muscle strength as well as expiratory muscle strength in patients with DMD (n= 32). The vital capacity (VC), maximum insufflation capacity (MIC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) were measured. Unassisted peak cough flow (UPCF) and three different techniques of assisted PCF were evaluated. The mean value of MICs (1918 +/- 586 mL) was higher than that of VCs (1474 +/- 632 mL) (p < 0.001). All three assisted cough methods showed significantly higher value than unassisted method (212 +/- 52 L/min) (F = 66.13, p < 0.001). Combined assisted cough technique (both manual and volume assisted PCF; 286 +/- 41 L/min) significantly exceeded manual assisted PCF (MPCF; 246 +/- 49 L/ min) and volume assisted PCF (VPCF; 252 +/- 45 L/min) (F = 66.13, p < 0.001). MIP (34 +/- 13 cmH2O) correlated significantly with both UPCF and all three assisted PCFs as well as MEP (27 +/- 10 cmH2O) (p < 0.001). Both MEP and MIP, which are the markers of respiratory muscle weakness, should be taken into account in the study of cough effectiveness.

Gene-transferring efficiencies of novel diamino cationic lipids with varied hydrocarbon chains.

Utilizing three biocompatible components, a series of novel cationic lipids has been chemically synthesized and tested for their gene-transferring capabilities in 293 transformed kidney cells and B16BL6 mouse melanoma cells. The synthesized cationic lipids consisting of a core of lysine and aspartic acid with hydrocarbon chains of varied length were assigned the acronyms DLKD (O,O'-dilauryl N-lysylaspartate), DMKD (O,O'-dimyristyl N-lysylaspartate), DPKD (O,O'-dipalmityl N-lysylaspartate), and DSKD (O,O'-distearyl N-lysylaspartate). The gene-transferring capabilities of these cationic lipids were found to be dependent on the hydrocarbon chain length. Under similar experimental conditions, the order of gene transfection efficiency was DMKD > DLKD > DPKD > DSKD. Addition of cholesterol or dioleoyl phosphatidylethanolamine (DOPE) as a colipid did not change this order. Colipid addition affected the transfection efficiency positively or negatively depending on the length of the cationic lipid acyl chain. On the whole, the length of the hydrophobic carbon chain was a major factor governing the gene-transferring capabilities of this series of cationic lipids. The observed differences in transfection efficiency may be due to differing binding affinities to DNA molecules as well as differences in the surface charge potential of the liposome-DNA complexes (lipoplexes) in the aqueous environment.