1.
Org Biomol Chem
; 10(48): 9601-19, 2012 Dec 28.
Article
in English
| MEDLINE
| ID: mdl-23132282
ABSTRACT
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.