ABSTRACT
The HLA-typing was carried out concerning of 200 residents of Novosibirsk, potential donors of hematopoietic stem cells on loci (HLA)-A, -B, -C, -DRB1. The study detected in mentioned population two new alleles non-registered previously by the WHO International Committee on nomenclature of factors of HLA-system. The analysis of distribution rates of HLA-alleles and haplotype revealed 16 alleles alternatives of locus HLA-A, 24-HLA-B, 13-HLA-C, 13-HLA-DRB1. The rate of frequency more than 10% is intrinsic to following allele alternatives: HLA-A*02 (29.25%), 01 (14%), 03 (13.5%), 24 (10.75%), HLA-B*35 (12.25%), 07 (12%), HLA-C*07 (29.75%), 06 (13%), 04 (12.5%), 12 (11.5%), 03 (10.75%), HLA-DRB*13 (15.25%), 07 (13.75%), 01 (13%), 11 (12.75%), 15 (12.75%), 04 (10.5%). The application of software Arlequin v. 3.1 established 239 possible gaplotypes HLA-AB-C-DRB1. The gaplotypes A*01-B*08-C*07-DRB1*03, A*02-B*13-C*06-DRB1*07, A*03-B*35-C*04-DRB1*01 with rate of frequency 4.5; 2.75 and 2,75% correspondingly. The The distribution of alleles and analysis of galotypes permitted to compare analyzed population with other Russian populations.
