Multiple contaminant ecological risk evaluation in small craft harbour sediments in Nova Scotia, Canada.

Small craft harbours are vital for the fishing industry and have high socioeconomic and cultural importance for surrounding communities. Presence of potential contaminants of concern in small craft harbour sediments can have significant impacts in biota and humans, including fishing activities and the local economy. While single contaminant sediment concentrations may be below sediment quality guidelines, the interaction of multiple contaminants in sediments may potentially exacerbate chemical ecological risk. An ecological risk evaluation for four classes of contaminants (i.e., petroleum hydrocarbons, polychlorinated biphenyls, polycyclic aromatic hydrocarbons and metals) was conducted in 31 small craft harbours in Nova Scotia, Canada, using two approaches (i.e., mean probable effect level quotient and number and frequency of sediment quality guideline exceedances). Most small craft harbours showed a low ecological risk to marine biota, with only two small craft harbours suggesting high risk. While urgent action is not needed, monitoring is recommended for these small craft harbours to confirm that pollution is not increasing, and to potentially identify and control contamination sources.

Spatiotemporal characterization of petroleum hydrocarbons and polychlorinated biphenyls in small craft harbour sediments in Nova Scotia, Canada.

Previous characterization of polycyclic aromatic hydrocarbons (PAHs) and metals has been conducted in small craft harbour (SCH) sediments in Nova Scotia, Canada, but petroleum hydrocarbons (PHCs) and polychlorinated biphenyls (PCBs) have not been spatiotemporally assessed. This study characterized the distribution of over 500 PHCs and PCBs samples in 31 SCHs sediments between 2000 and 2017. Federal and regional sediment quality guidelines were used to determine exceedances. Results showed exceedances for diesel and oil resembling PHCs, expected given their longer permanence in sediments and lower volatility. However, only 7% of the samples exceeded 500 ppm, threshold where benthic impairment is observed, showing low risk. PCBs do not pose high risk to biota since only six samples exceeded the higher effect level and 25% of them exceeded the lower effect one. Monitoring is recommended for SCHs with significant exceedances, as well as collectively assessing all contaminants characterized in SCHs.

The five-repetition sit-to-stand test is a predictive factor of severe exacerbations in COPD.

BACKGROUND: Although the six-minute-walk test (6MWT) has been used to predict chronic obstructive pulmonary disease (COPD) exacerbations, additional research is necessary to identify more rapid, simpler tests that are directly associated with exacerbations, such as the five-repetition sit-to-stand (5STS) test and 4-m gait speed (4MGS) test. AIMS: To determine the ability of the 5STS and 4MGS tests in predicting severe exacerbations in stable COPD over the following year, and to assess the ability of the best prognostic test to identify patients at high risk of hospital admission correctly. METHODS: This prospective study included 137 patients with stable COPD. Multiple logistic regression models were constructed to assess whether the 6MWT, 5STS, and 4MGS tests were associated with severe exacerbations in the year following the test. Receiver-operating characteristic curves and the area under the curve (AUC) were evaluated to determine the accuracy of each test for identifying patients with severe exacerbations. RESULTS: Scores of <350 m for the 6WMT and ⩽2 for the 5STS test were associated with severe exacerbations in the model adjusted for age and the number of exacerbations in the previous year. The 5STS test and the 6MWT had very similar predictive and discriminative abilities. Odds ratios were 3.20 (95% confidence interval [CI] 1.14-8.96) and 3.84 (95% CI 1.14-12.94) and AUCs were 0.793 (95% CI 0.704-0.882) and 0.783 (95% CI 0.686-0.879), respectively. CONCLUSIONS: The 5STS test predicted the risk of severe exacerbation within the following year among patients with COPD. The 5STS test could replace the 6MWT for identifying patients at high risk of hospital admission.

Mobility limitations related to reduced pulmonary function among aging people with chronic obstructive pulmonary disease.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of disability. We aimed to analyse the impact of reduced pulmonary function on non-respiratory impairments and mobility activity limitations in an elderly population with COPD and to elucidate which specific limitations on mobility are related to reduced pulmonary function. METHODS: Cross-sectional study of 110 patients with COPD, recruited from public and university hospital. The effect of impaired pulmonary function on the risk of non-respiratory impairments and mobility limitations was analysed using validated measures, including: the 6-Minute Walk Test (6MWT), skeletal muscle strength, the Short Physical Performance Battery (SPPB), and self-reported mobility questionnaire. Multivariate analysis was used to control for confounders such as age, sex, height, education, and cigarette smoking. RESULTS: Greater impairment of pulmonary function was associated with less distance walked during the 6MWT, poorer SPPB scores, and greater risk of self-reported mobility limitations (p<0.05). Lower forced expiratory volume in 1 s was also associated with a greater risk of limitations in carrying items under 10 pounds (4.54 kg), walking alone up and down a flight of stairs, and walking two or three neighbourhood blocks. There was no clear statistical relationship between pulmonary function impairment and skeletal muscle strength. CONCLUSIONS: Impaired pulmonary function was associated with the 6MWT score and limitations on performance-based and self-reported mobility activities, but not with skeletal muscle strength among elderly COPD patients.