ABSTRACT
Previously undescribed carbamazepine fluorescence data were found in ethanolic solutions within a range of 200-550 nm. Concentrated H2S04, bidistilled ethanol and a 1:1 mixture of them showed lambda Exc. at 470 nm. A 10-fold fluorescence increase at 470 nm and 520 nm peaks were observed when 10 micrograms of ethanolic carbamazepine solution was activated with the same acid (1:1). A lambda Exc. of 300 nm and Anal. of 357 nm amounted to 60 per cent of the carbamazepine relative fluorescence values in comparison to 95 per cent when a 470/515 nm monochromators combination were used. A 12 hours fluorescence duration was detected for "activated" carbamazepine. The "filter effect" appeared within the range of 10 and 100 micrograms/ml of carbamazepine. Temperature induced an acute fluorescence decay starting at 23 degrees C. Identical wavelengths and others still unidentified were detected from carbamazepine extracted from human serum. The monochromators combination at 300/357 nm might be useful for serum extracted carbamazepine measurements.
Subject(s)
Carbamazepine , Ethanol , Fluorescence , Solutions , Spectrometry, Fluorescence , Sulfuric AcidsABSTRACT
Describimos las caracteristicas fluorescentes de la carbamacepina. Esta, en solucion etanoliga, manifiesta lambda exc. a 470 y 520 nm.El etanol no muestra maximos de excitacion entre 200 y 550 nm; en cambio, el H2SO4 concentrado y su mezcla etanolica lo hacen a 479 nm, en proporcion 10 veces menor en ausencia de carbamacepina. Una meseta a lambda exc.de 300 nm y una lambda de anal de 357 brindan valores de 60 por ciento, en comparacion con 95 por ciento de fluorescencia relativa encontrados con la combinacion 470/515 nm para 10 micrograma de carbamacepina. Se detecta una duracion de 12 horas de la fluorescencia correspondiente a la carbamacepina "activada" El efecto de filtro se manifiesta entre los 10 y los 100 micrograma. La temperatura induce la declinacion de la emision despues de los 23oC hasta llegar a valores del reactivo de activacion a los 25oC. La carbamacepina extraida de suero humano revela las mismas lambdas exc. y valores intermedios correspondientes a compuestos sericos no investigados