Epidemiologia das urgências e emergências oftalmológicas em um Hospital Universitário Terciário / Epidemiologic profile of ophthalmic emergencies in a Tertiary University Hospital

Resumo O estudo buscou analisar e estudar a prevalência e as circunstâncias de urgências e emergências oftalmológicas no Pronto Socorro do Hospital de Clínicas de Uberlândia da Universidade Federal de Uberlândia (HCU-UFU) e no Ambulatório Amélio Marques no período de agosto de 2016 a agosto de 2017. Faz-se necessário tal estudo, pois emergências oftalmológicas são importantes causas de morbidades na sociedade(1). Ademais, através dele políticas de prevenção poderão ser feitas, além de maior capacitação de profissionais a partir do conhecimento das principais causas de atendimento. A metodologia proposta incluiu a coleta de dados do prontuário, sendo colhidas as informações sexo, idade e ocupação/profissão. Trata-se de um estudo epidemiológico exploratório observacional predominantemente descritivo do tipo transversal. O trabalho evidenciou que o sexo masculino foi o mais acometido e a faixa etária mais incidente foi entre 19 e 45 anos. Das causas de procura pelo pronto-atendimento oftalmológico, o trauma ocular por corpo estranho é a mais comum havendo uma estreita relação com as atividades laborais (mecânicos e ferragistas). Dessa forma, os dados serão um recurso importante para o auxiliar na compreensão do perfil epidemiológico do pronto-atendimento oftalmológico visando otimizar a administração do mesmo e para estimular a adoção de políticas públicas de prevenção no âmbito da saúde do trabalhador.

Abstract The study aimed to analyze and study the prevalence and circumstances of ophthalmic emergencies and urgencies in the Emergency Room of the Hospital de Clínicas de Uberlândia and the Central Ambulatory (Amélio Marques) of the Federal University of Uberlândia (HCU-UFU) from August 2016 to August 2017. This is a necessary study since ophthalmic emergencies are important causes of morbidities in society(1). In addition, this study will help to develop prevention policies and to make greater training of professionals based on knowledge of the main causes of eye emergencies. The proposed methodology included the collection of data from the medical record, with the information of sex, age and occupation/profession being collected. This is an observational, descriptive, transversal, exploratory epidemiological study. The study showed that males were the most affected and the most incident age group was between 19 and 45 years old. Eye trauma due to a foreign body is the most common cause of demand for ophthalmologic emergency care with a close relationship with work activities (mechanics and ironmongers). In this way, the data will be an important resource to assist in understanding the epidemiological profile of the ophthalmology emergency room in order to optimize its administration and to encourage the adoption of public prevention policies within the scope of occupational health.

Pulmonary Rehabilitation in COPD According to Global Initiative for Chronic Obstructive Lung Disease Categories.

BACKGROUND: Pulmonary rehabilitation (PR) programs are a mainstay for treatment in COPD. Lung function impairment alone does not predict beneficial effects of PR. The new COPD categories take into account assessment of symptoms, such as dyspnea and exacerbations, which may be important indications for PR. This study evaluates the effect of PR on exercise capacity, symptoms, and health status in different COPD categories. METHODS: Subjects with COPD referred for PR were classified into COPD categories A, B, C, and D. Exercise capacity (6-min walk distance [6MWD] and constant work rate at 80% of peak work rate), symptoms (Mahler's index), and health status (St George Respiratory Questionnaire) were compared before and after PR programs for each COPD category. Changes were analyzed using generalized estimating equations and logistic regression models. RESULTS: One hundred sixty-seven subjects were included (COPD categories A [16%], B [12%], C [31%], and D [41%]). Groups were homogeneous in age, body mass index, smoking pack-years, and comorbidities. Significant improvements in all outcomes were found after adjusting for COPD categories, age, sex, body mass index, and COPD-specific comorbidity index. All COPD categories improved exercise capacity (6MWD and constant work rate). Categories A and C had more pronounced improvements in 6MWD than categories B and D. Symptoms (Mahler's index) also improved significantly in categories A and C, whereas change was not significant in categories B and D. Global health status (St George Respiratory Questionnaire) improved significantly in all COPD categories. Despite these differences, the odds of achieving a minimum clinically important difference in each outcome were similar and without statistical significance for the A, B, and C categories when compared with D. CONCLUSIONS: This study demonstrates that patients in all COPD categories may improve exercise capacity, symptoms, and health status with PR programs, and COPD categories alone may not be sufficient to discriminate which patients may benefit most from them.

Pulmonary Rehabilitation in COPD: Effect of 2 Aerobic Exercise Intensities on Subject-Centered Outcomes--A Randomized Controlled Trial.

BACKGROUND: Exercise training is an important component of pulmonary rehabilitation, but it remains questionable how training intensity affects patient-centered outcomes. The aim of this study was to compare the effects of 2 aerobic training intensities on health-related quality of life (HRQOL), symptom control, and exercise tolerance in subjects with COPD. METHODS: Thirty-four subjects with mild to very severe COPD participated in an equivalence/non-inferiority randomized controlled trial with a parallel group blinded to 60 or 80% maximum work rate (W max) aerobic training intensity. The intervention was an out-patient pulmonary rehabilitation program conducted 3 times/week for 8 weeks. Outcomes were assessed with the St George Respiratory Questionnaire (primary outcome), Mahler's dyspnea index, London Chest Activity of Daily Living scale, 6-min walk test, and constant-load and incremental exercise tests. RESULTS: Subjects were randomly allocated to aerobic training intensity of 60% W max (group 1, n = 17) or 80% W max (group 2, n = 17). Although there were significant improvements in all outcomes for both groups, there were no between-group differences in mean change in the St George Respiratory Questionnaire (P = .31, 95% CI -12.0 to 3.9), Mahler's dyspnea index (P = .38), London Chest Activity of Daily Living scale (P = .92), 6-min walk test (P = .50, 95% CI 6.2-71.1), constant-load exercise test (P = .50), and incremental exercise test (P = .12). There was only one exercise-related adverse event of cardiac symptoms. CONCLUSIONS: Aerobic training intensity of at least 60% W max has a positive impact on COPD patient-centered outcomes, with no additional benefit of increasing intensity to 80% W max in HRQOL, symptom control, and exercise tolerance, challenging the present clinical attitude of rehabilitation professionals. (ClinicalTrials.gov registration NCT01944072.).

Chemical composition of the essential oil from Microlicia graveolens growing wild in Minas Gerais

The chemical composition of the essential oil of the aerial parts of Microlicia graveolens DC., Melastomataceae, growing wild in the mountains of Minas Gerais, Brazil, was investigated for the first time. A pale orange to colourless oil was obtained in a yield of 4.8%. The oil was analyzed by GC-MS. The main components were (+)-trans-pinocarvyl acetate (78.9%), (-)-trans-pinocarvyl acetate (5.5%) and β-pinene (3.8%).

Salmonella sp. in game (Sus scrofa and Oryctolagus cuniculus).

The role of wildlife in the epidemiology of Salmonella sp.-induced diseases is a matter of increasing concern to public health. However, to date, reports on the occurrence of Salmonella sp. in game hunted for human consumption are very limited. The current study was designed to evaluate the prevalence of Salmonella sp. in fecal samples of wild boars and wild rabbits hunted in Northern Portugal. The results show that 22% of the (17/77) wild boar and 48% (38/80) of the wild rabbit presented Salmonella sp. in their feces. Two serovars were identified from samples of wild boars: Salmonella Typhimurium (65%) and Salmonella Rissen (35%). Five serovars were identified from wild rabbit samples: Salmonella Rissen (29%), Salmonella Enteritidis (26%), Salmonella Havana (24%), Salmonella Typhimurium (16%), and Salmonella Derby (5%). These results confirm the importance of wild boar and wild rabbit as carriers of pathogenic Salmonella serovars. Hence, they could represent sources of infection not only for animals (wild and domestic) but also for humans.

Venous thromboembolism risk factors and practices of prophylaxis: ENDORSE study results in Portugal.

BACKGROUND: Venous thromboembolism (VTE) risk assessment is a cornerstone for the achievement of best practices and outcomes. Epidemiologic data and practices related to venous thromboprophylaxis as considered by the global ENDORSE study, (Epidemiologic International Day for the Evaluation of Patients at Risk for Venous Thromboembolism in the Acute Hospital Care Setting), enrolled 68,183 patients from 32 countries, in which Portugal. Within ENDORSE, data from all participant countries analyzed to determine their risk of VTE and to evaluate the suitability of prophylaxis. METHODS: European patients were enrolled from randomly selected hospitals in Portugal (European Hospital Register), according to ENDORSE study inclusion/exclusion criteria. The Seventh ACCP evidence-based consensus guidelines were employed to evaluate VTE risk and prophylaxis use. RESULTS: From a total of 3,145 beds assessed, 2,183 were considered eligible and 1,632 met all criteria. Of these, 860 (52.7%; 95% CI 50.3-55.1) were at risk of VTE: 525 surgical patients (68.9%; 95% CI 65.5-72.1) and 335 medical patients (38.5%; 95% CI 35.3-41.2). The rate of prophylaxis according to ACCP guidelines in overall patients at risk was 58.5% (503 patients). The prophylaxis rate for VTE was 59% (310 patients) in surgical patients and 57.6% (n=193) in medical patients. 39.7% of surgical patients and 39.4 % of medical patients who did not meet the criteria for prophylaxis were also on prophylaxis with an anticoagulant, which was considered to be inappropriate. CONCLUSIONS: More than a half of these hospitalized patients in Portugal were deemed at risk of VTE and less than two-thirds of them received appropriate prophylaxis. New strategies are required for implementation of venous thromboprophylaxis in Portuguese hospitals.

[Exercise training in chronic pulmonary disease]. / Treino de exercício na doença pulmonar crónica.

Exercise training has become a cornerstone of Pulmonary Rehabilitation. Since the nineties, the effectiveness in clinically relevant improvements in exercise capacity and health-related quality of life has been proved. Current guidelines (Evidence A) recommend high intensity continuous exercise for lower extremities as the most effective exercise modality, however, for some patients it is often difficult to initiate such an exercise programme due to the limitation of dyspnoea or leg fatigue. In recent years, special relevance has been given to the integration of other modalities of exercise (continuous versus interval, aerobic versus strength, inclusion or not of respiratory muscle training). The authors carry out a review of the current literature concerning exercise training in chronic pulmonary disease and this highlights the role of tailored exercise to break the vicious cycle of dyspnoea and inactivity.