ABSTRACT
From June 1987 thru December 1988, 72 patients entered our gamete intrafallopian transfer (GIFT) program. The average age of our patients was 28 years with of infertility. The causes for being selected to the program were: Unknown (14), Endometriosis (14), Male (13), Ovarian (5), Cervical (9), Tubo-peritoneal (6) and oocyte donation (11). Different follicular stimulation protocols were used, with combinations of clomiphene citrate, human menopausal gonadotropins (hMG) and follicle stimulating hormone (FSH). Monitoring by serial ultrasound scanning until two or more follicles were 16-18 mm and estradiol levels were over 700 pg/ml, after which 10,000 IU of human chorionic gonadotropins (hCG) were injected. After 36 hrs oocyte retrieval was performed. There were 19 clinical pregnancies (26.4%). We feel that this new technique offers a bright and promising future for our infertile population.
Subject(s)
Gamete Intrafallopian Transfer , Infertility/therapy , Adult , Evaluation Studies as Topic , Female , Humans , Infertility, Female/therapy , PregnancyABSTRACT
Two patients were admitted to our Gamete Intrafallopian Transfer (GIF) program, and received and ovulation stimulation protocol with Clomiphene Citrate and human menopausal gonadotropin (hMG). Human chorionic gonadotropin (hCG, 10,000 IU IM) was administered when follicle size achieved 18 mm adn oocyte retrieval was scheduled after 36 hours. The estradiol levels in both patients were 1,127 pg/ml respectively at the time hCG was administered, which demonstrates an excellent response to the stimulation. Follicle aspiration was accomplished by transvaginal ultrasound-guided puncture or laparoscopy, and we were unable to recover oocytes in 17 follicles. Our findings support the existence of the "Empty Follicle Syndrome". This pathology may explain some of the infertility causes of our sterile population.
Subject(s)
Infertility, Female/etiology , Oocytes , Ovarian Follicle , Adult , Female , Humans , Ovulation Induction , SyndromeABSTRACT
Gamete intrafallopian transfer (GIFT) was performed in 11 patients with premature gonadal failure and infertility, with oocyte donation. The sustitutive estrogen therapy with Estradiol Valerinate and Progesterone was maintained up to 100 days after the transfer. In all the cases GIFT was performed between the day 13 and 70 of the cycle. There were 5 pregnancies out of 11 cycles (success rate of 45.4%), one ended with a live child and the four others are on their first, second and third trimester. We are presenting a modified and simplified new protocol for hormonal replacement and our results suggest a new and wide "endometrial window" for the management of this patients. This results offer a promising future for patients with premature gonadal failure.
