ABSTRACT
BACKGROUND Paraneoplastic cerebellar degeneration (PCD) is a rare condition that can present as an acute or subacute cerebellar syndrome. PCD is most commonly associated with gynecological and breast cancer, small-cell lung cancer, and classical Hodgkin's lymphoma. The symptoms of PCD can arise several months before tumor diagnosis. This report is of a case of a 44-year-old man with PCD that preceded the diagnosis of classical Hodgkin's lymphoma by 16 months. CASE REPORT A 44-year-old man was admitted to hospital with a cerebellar syndrome that was initially diagnosed as vertebrobasilar insufficiency. Eight months later, cerebral magnetic resonance imaging (MRI) findings and serum anti-Tr antibodies supported the diagnosis of PCD, but no underlying malignancy was initially found. At 16 months after the initial diagnosis of PCD, the patient developed an enlarged inguinal lymph node. Histology of the excisional lymph node biopsy confirmed the diagnosis of classic mixed cellularity Hodgkin's lymphoma, Ann Arbor stage IIA. The patient responded to four cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. CONCLUSIONS This case illustrates that in patients who present with PCD, an associated malignancy, such as classical Hodgkin's lymphoma, may emerge several months later, which supports long-term follow-up. The presence of anti-Tr antibodies may support a diagnosis of classical Hodgkin's lymphoma in a patient with a history of PCD who develops lymphadenopathy.
Subject(s)
Hodgkin Disease/diagnosis , Paraneoplastic Cerebellar Degeneration/diagnostic imaging , Adult , Antibiotics, Antineoplastic/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Bleomycin/therapeutic use , Dacarbazine/therapeutic use , Doxorubicin/therapeutic use , Hodgkin Disease/complications , Hodgkin Disease/drug therapy , Humans , Magnetic Resonance Imaging , Male , Paraneoplastic Cerebellar Degeneration/complications , Vinblastine/therapeutic useABSTRACT
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Subject(s)
Aged , Humans , Infarction/complications , Infarction/diagnosis , Ischemic Attack, Transient/complications , Ischemic Attack, Transient/diagnosis , Benign Paroxysmal Positional Vertigo/complications , Benign Paroxysmal Positional Vertigo/etiology , Nystagmus, Pathologic/complications , Nystagmus, Pathologic/diagnosis , Platelet Aggregation Inhibitors/therapeutic use , Cerebellar Cortex/pathology , Cerebellum/pathology , Cerebral Arteries/pathology , Risk Factors , Gait Disorders, Neurologic/complications , Gait Disorders, Neurologic/diagnosis , Gait Disorders, Neurologic/etiologySubject(s)
Brain Infarction/diagnosis , Cerebellum/blood supply , Aged , Diagnosis, Differential , Female , HumansABSTRACT
La invaginación basilar se presenta cuando por alguna causa congénita o adquirida, el proceso odontoideo de la segunda vértebra cervical presiona estructuras nerviosas medulares o de la porción alta del cordón espiral resultando en una multiplicidad de síntomas. En este artículo se presentan dos casos de invaginación basilar cuyo acceso quirúrgico fue a través de una maxilotomía Le Fort I. De igual forma se hace revisión bibliográfica del tema y se presentan las ventajas y desventajas de la técnica
Subject(s)
Humans , Male , Adult , Maxilla/surgery , Odontoid Process/surgery , Osteotomy , Skull/abnormalitiesABSTRACT
La colocación simultánea de implantes endóseos en alveolos dentales post-extracción ofrece múltiples ventajas, siendo una de las principales una disminución de morbilidad. Es un procedimiento que se utiliza rutinariamente en la práctica odontológica contemporánea con resultados predecibles siempre y cuando se lleve a cabo un diagnóstico adecuado. Se presenta una revisión de la literatura y casos clínicos
Subject(s)
Humans , Male , Adolescent , Adult , Dental Implantation, Endosseous , Tooth Extraction , Radiography, PanoramicABSTRACT
La enfermedad osteorradionecrosis provoca defectos de tipo estético funcional afectando al paciente de forma física, fisiológica y psicológica. En un gran número de los casos el proceso patológico puede evitarse desde antes de iniciar el tratamiento de radioterapia. El oxígeno hiperbárico es de suma importancia en el manejo de estos pacientes desde el punto de vista preventivo y terapéutico. Se presenta una revisión de la literatura y presentación de casos clínicos
